PUBLICATION
Quinolizidine alkaloids from Sophora tonkinensis and their anti-inflammatory activities
- Authors
- He, L.J., Liu, J.S., Luo, D., Zheng, Y.R., Zhang, Y.B., Wang, G.C., Li, Y.L.
- ID
- ZDB-PUB-191226-1
- Date
- 2019
- Source
- Fitoterapia 139: 104391 (Journal)
- Registered Authors
- Keywords
- Alkaloid, Anti-inflammatory activity, Sophora tonkinensis Gagnep.
- MeSH Terms
-
- Alkaloids/isolation & purification
- Alkaloids/pharmacology*
- Animals
- Animals, Genetically Modified
- Anti-Inflammatory Agents/isolation & purification
- Anti-Inflammatory Agents/pharmacology*
- Azocines
- China
- Mice
- Molecular Structure
- Phytochemicals/isolation & purification
- Phytochemicals/pharmacology
- Plant Roots/chemistry
- Quinolizidines/isolation & purification
- Quinolizidines/pharmacology*
- Quinolizines
- RAW 264.7 Cells
- Sophora/chemistry*
- Zebrafish
- PubMed
- 31682871 Full text @ Fitoterapia
Citation
He, L.J., Liu, J.S., Luo, D., Zheng, Y.R., Zhang, Y.B., Wang, G.C., Li, Y.L. (2019) Quinolizidine alkaloids from Sophora tonkinensis and their anti-inflammatory activities. Fitoterapia. 139:104391.
Abstract
Two new quinolizidine-based alkaloids (2 and 12), along with ten known ones (1, 3-11) were isolated from the roots of S. tonkinensis. Their structures were determined by spectroscopic data (including NMR, MS, IR, and UV), X-ray single crystal diffraction, electronic circular dichroism analyses (ECD), and comparing with related literatures. Compounds 1, 3-12 at non-toxic concentrations exhibited potent anti-inflammatory activities according to in vitro and in vivo anti-inflammatory tests. Among them, (-)-anagyrine (4), sophocarpine (8), 14β-hydroxymatrine (10), and 7β-sophoramine (12) showed more potent in vitro anti-inflammatory activities, and 5α,14β-dihydroxymatrine (2), (-)-anagyrine (4), sophocarpine (8), and 5α-hydroxymatrine (9) exhibited better in vivo anti-inflammatory effects.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping