PUBLICATION
Bisphenol F exposure impairs neurodevelopment in zebrafish larvae (Danio rerio)
- Authors
- Gu, J., Wu, J., Xu, S., Zhang, L., Fan, D., Shi, L., Wang, J., Ji, G.
- ID
- ZDB-PUB-191106-22
- Date
- 2019
- Source
- Ecotoxicology and environmental safety 188: 109870 (Journal)
- Registered Authors
- Keywords
- BPF, Neurodevelopment, Oxidative stress
- MeSH Terms
-
- Animals
- Apoptosis/drug effects
- Benzhydryl Compounds/toxicity*
- Brain/drug effects*
- Brain/growth & development
- Environmental Exposure
- Female
- Locomotion/drug effects
- Male
- Oxidative Stress/drug effects
- Phenols/toxicity*
- Water Pollutants, Chemical/toxicity*
- Zebrafish/embryology*
- Zebrafish/growth & development
- PubMed
- 31683046 Full text @ Ecotoxicol. Environ. Saf.
Citation
Gu, J., Wu, J., Xu, S., Zhang, L., Fan, D., Shi, L., Wang, J., Ji, G. (2019) Bisphenol F exposure impairs neurodevelopment in zebrafish larvae (Danio rerio). Ecotoxicology and environmental safety. 188:109870.
Abstract
BPF, a substitute of BPA, has been widely detected in environment and human bodies. Although the genotoxicity, endocrine disrupting effects, reproductive toxicity of BPF has been well documented, its neurodevelopmental toxicity still remains nebulous. In our study, zebrafish embryos were exposed to BPF treatment (0, 7, 70 and 700 μg/L) for 3 or 6 days. Our results showed that BPF exposure markedly decreased zebrafish locomotor behavior, increased oxidative stress, promoted apoptosis and altered brain structure in zebrafish. In addition, the expressions of neurodevelopment related genes were also downregulated upon BPF treatment. In conclusion, our results systematically demonstrated the developmental neurotoxicity of BPF in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping