PUBLICATION
Efferent modulation of spontaneous lateral line activity during and after zebrafish motor commands
- Authors
- Lunsford, E.T., Skandalis, D.A., Liao, J.C.
- ID
- ZDB-PUB-191024-4
- Date
- 2019
- Source
- Journal of neurophysiology 122(6): 2438-2448 (Journal)
- Registered Authors
- Keywords
- cholinergic efferent neurons, corollary discharge, hair cells, lateral line, locomotion
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology
- Electrophysiological Phenomena/physiology*
- Larva
- Lateral Line System/physiology*
- Locomotion/physiology*
- Neurons, Afferent/physiology*
- Neurons, Efferent/physiology*
- Rhombencephalon/physiology*
- Zebrafish
- PubMed
- 31642405 Full text @ J. Neurophysiol.
Citation
Lunsford, E.T., Skandalis, D.A., Liao, J.C. (2019) Efferent modulation of spontaneous lateral line activity during and after zebrafish motor commands. Journal of neurophysiology. 122(6):2438-2448.
Abstract
Accurate sensory processing during movement requires the animal to distinguish between external and self-generated stimuli to maintain sensitivity to biologically relevant cues. The lateral line system in fishes is a mechanosensory organ that experiences sensory feedback via detection of fluid motion relative to the body generated during behaviors such as swimming. For the first time in larval zebrafish (Danio rerio), we employed simultaneous recordings of lateral line and motor activity to reveal the effect of endogenous feedback from hindbrain efferent neurons during locomotion. Frequency of spontaneous spiking in posterior lateral line afferent neurons decreased during motor activity. Targeted photoablation of efferent neurons abolished the afferent inhibition that was correlated to swimming, indicating that inhibitory efferent neurons are necessary for modulating lateral line sensitivity during locomotion. We monitored calcium activity with Tg(elav13:GCaMP6s) fish and found synchronous activity between putative cholinergic efferent neurons and motor neurons. We examined correlates of motor activity to determine which may best predict the attenuation of afferent activity and therefore what components of the motor signal are translated through the corollary discharge. Attenuated spike frequency persisted past the end of the fictive swim bout, suggesting that corollary discharge also affects the glide phase of burst and glide locomotion. The duration of the glide in which spike frequency was attenuated increased with swim duration but decreased with motor frequency. Our results detail a neuromodulatory mechanism in larval zebrafish that adaptively filters self-generated flow stimuli during both the active and passive phases of locomotion.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping