PUBLICATION

Prepontine non-giant neurons drive flexible escape behavior in zebrafish

Authors
Marquart, G.D., Tabor, K.M., Bergeron, S.A., Briggman, K.L., Burgess, H.A.
ID
ZDB-PUB-191016-9
Date
2019
Source
PLoS Biology   17: e3000480 (Journal)
Registered Authors
Bergeron, Sadie, Burgess, Harold, Marquart, Gregory, Tabor, Kathryn
Keywords
none
MeSH Terms
  • Animals
  • Decision Making/physiology
  • Escape Reaction/physiology*
  • Larva/physiology
  • Motor Cortex/cytology
  • Motor Cortex/physiology*
  • Motor Neurons/cytology
  • Motor Neurons/physiology*
  • Pattern Recognition, Physiological/physiology*
  • Pons/cytology
  • Pons/physiology*
  • Reaction Time/physiology
  • Zebrafish/physiology*
PubMed
31613896 Full text @ PLoS Biol.
Abstract
Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level. However, how sensory cues are integrated within premotor escape circuits remains poorly understood. Here, we show that in zebrafish, less precipitous threats elicit a delayed escape, characterized by flexible trajectories, which are driven by a cluster of 38 prepontine neurons that are completely separate from the fast escape pathway. Whereas neurons that initiate rapid escapes receive direct auditory input and drive motor neurons, input and output pathways for delayed escapes are indirect, facilitating integration of cross-modal sensory information. These results show that rapid decision-making in the escape system is enabled by parallel pathways for ballistic responses and flexible delayed actions and defines a neuronal substrate for hierarchical choice in the vertebrate nervous system.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes