PUBLICATION
Prepontine non-giant neurons drive flexible escape behavior in zebrafish
- Authors
- Marquart, G.D., Tabor, K.M., Bergeron, S.A., Briggman, K.L., Burgess, H.A.
- ID
- ZDB-PUB-191016-9
- Date
- 2019
- Source
- PLoS Biology 17: e3000480 (Journal)
- Registered Authors
- Bergeron, Sadie, Burgess, Harold, Marquart, Gregory, Tabor, Kathryn
- Keywords
- none
- MeSH Terms
-
- Animals
- Pattern Recognition, Physiological/physiology*
- Reaction Time/physiology
- Motor Neurons/cytology
- Motor Neurons/physiology*
- Motor Cortex/cytology
- Motor Cortex/physiology*
- Escape Reaction/physiology*
- Zebrafish/physiology*
- Larva/physiology
- Pons/cytology
- Pons/physiology*
- Decision Making/physiology
- PubMed
- 31613896 Full text @ PLoS Biol.
Citation
Marquart, G.D., Tabor, K.M., Bergeron, S.A., Briggman, K.L., Burgess, H.A. (2019) Prepontine non-giant neurons drive flexible escape behavior in zebrafish. PLoS Biology. 17:e3000480.
Abstract
Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level. However, how sensory cues are integrated within premotor escape circuits remains poorly understood. Here, we show that in zebrafish, less precipitous threats elicit a delayed escape, characterized by flexible trajectories, which are driven by a cluster of 38 prepontine neurons that are completely separate from the fast escape pathway. Whereas neurons that initiate rapid escapes receive direct auditory input and drive motor neurons, input and output pathways for delayed escapes are indirect, facilitating integration of cross-modal sensory information. These results show that rapid decision-making in the escape system is enabled by parallel pathways for ballistic responses and flexible delayed actions and defines a neuronal substrate for hierarchical choice in the vertebrate nervous system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
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