PUBLICATION
LIN28B increases neural crest cell migration and leads to transformation of trunk sympathoadrenal precursors
- Authors
- Corallo, D., Donadon, M., Pantile, M., Sidarovich, V., Cocchi, S., Ori, M., De Sarlo, M., Candiani, S., Frasson, C., Distel, M., Quattrone, A., Zanon, C., Basso, G., Tonini, G.P., Aveic, S.
- ID
- ZDB-PUB-191012-3
- Date
- 2019
- Source
- Cell death and differentiation 27(4): 1225-1242 (Journal)
- Registered Authors
- Aveic, Sanja, Corallo, Diana, Distel, Martin, Pantile, Marcella
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Differentiation
- Cell Line, Tumor
- Cell Movement*
- Epithelial-Mesenchymal Transition
- Focal Adhesion Protein-Tyrosine Kinases/metabolism
- Focal Adhesions/metabolism
- Humans
- Integrins/metabolism
- Neural Crest/cytology*
- Neurons/cytology
- Neurons/metabolism
- Phenotype
- RNA-Binding Proteins/metabolism*
- Signal Transduction
- Stem Cells/metabolism*
- Sympathoadrenal System/cytology*
- Torso/physiology*
- Xenopus Proteins/metabolism*
- Xenopus laevis
- Zebrafish
- Zebrafish Proteins/metabolism*
- PubMed
- 31601998 Full text @ Cell Death Differ.
Citation
Corallo, D., Donadon, M., Pantile, M., Sidarovich, V., Cocchi, S., Ori, M., De Sarlo, M., Candiani, S., Frasson, C., Distel, M., Quattrone, A., Zanon, C., Basso, G., Tonini, G.P., Aveic, S. (2019) LIN28B increases neural crest cell migration and leads to transformation of trunk sympathoadrenal precursors. Cell death and differentiation. 27(4):1225-1242.
Abstract
The RNA-binding protein LIN28B regulates developmental timing and determines stem cell identity by suppressing the let-7 family of microRNAs. Postembryonic reactivation of LIN28B impairs cell commitment to differentiation, prompting their transformation. In this study, we assessed the extent to which ectopic lin28b expression modulates the physiological behavior of neural crest cells (NCC) and governs their transformation in the trunk region of developing embryos. We provide evidence that the overexpression of lin28b inhibits sympathoadrenal cell differentiation and accelerates NCC migration in two vertebrate models, Xenopus leavis and Danio rerio. Our results highlight the relevance of ITGA5 and ITGA6 in the LIN28B-dependent regulation of the invasive motility of tumor cells. The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms.
Errata / Notes
This article is corrected by ZDB-PUB-220906-180 .
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping