PUBLICATION
Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area
- Authors
- Frank, T., Mönig, N.R., Satou, C., Higashijima, S.I., Friedrich, R.W.
- ID
- ZDB-PUB-191011-4
- Date
- 2019
- Source
- Nature Neuroscience 22(11): 1844-1856 (Journal)
- Registered Authors
- Friedrich, Rainer, Higashijima, Shin-ichi
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Association Learning/physiology*
- Brain Mapping*
- Discrimination Learning/physiology
- Female
- Individuality
- Male
- Neural Inhibition/physiology*
- Odorants
- Olfactory Cortex/physiology*
- Olfactory Perception/physiology*
- Zebrafish
- PubMed
- 31591559 Full text @ Nat. Neurosci.
Citation
Frank, T., Mönig, N.R., Satou, C., Higashijima, S.I., Friedrich, R.W. (2019) Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area. Nature Neuroscience. 22(11):1844-1856.
Abstract
Intelligent behavior involves associations between high-dimensional sensory representations and behaviorally relevant qualities such as valence. Learning of associations involves plasticity of excitatory connectivity, but it remains poorly understood how information flow is reorganized in networks and how inhibition contributes to this process. We trained adult zebrafish in an appetitive odor discrimination task and analyzed odor representations in a specific compartment of the posterior zone of the dorsal telencephalon (Dp), the homolog of mammalian olfactory cortex. Associative conditioning enhanced responses with a preference for the positively conditioned odor. Moreover, conditioning systematically remapped odor representations along an axis in coding space that represented attractiveness (valence). Interindividual variations in this mapping predicted variations in behavioral odor preference. Photoinhibition of interneurons resulted in specific modifications of odor representations that mirrored effects of conditioning and reduced experience-dependent, interindividual variations in odor-valence mapping. These results reveal an individualized odor-to-valence map that is shaped by inhibition and reorganized during learning.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping