PUBLICATION
Tryptophan alleviates neuroendocrine and behavioral responses to stress in zebrafish
- Authors
- Giacomini, A.C.V.V., Piassetta, A.S., Genario, R., Bonan, C.D., Piato, A., Barcellos, L.J.G., de Abreu, M.S.
- ID
- ZDB-PUB-191001-12
- Date
- 2019
- Source
- Behavioural brain research 378: 112264 (Journal)
- Registered Authors
- Bonan, Carla Denise
- Keywords
- anxiety, behavior, cortisol, fluoxetine, zebrafish
- MeSH Terms
-
- Animals
- Anxiety/etiology
- Anxiety/metabolism
- Anxiety/physiopathology
- Anxiety/prevention & control*
- Behavior, Animal*/drug effects
- Behavior, Animal*/physiology
- Disease Models, Animal
- Female
- Fluoxetine/administration & dosage
- Fluoxetine/pharmacology*
- Hydrocortisone/metabolism*
- Male
- Serotonin Agents/administration & dosage
- Serotonin Agents/pharmacology*
- Stress, Psychological/complications
- Stress, Psychological/drug therapy*
- Stress, Psychological/metabolism
- Stress, Psychological/physiopathology
- Tryptophan/administration & dosage
- Tryptophan/pharmacology*
- Zebrafish
- PubMed
- 31568833 Full text @ Behav. Brain Res.
Citation
Giacomini, A.C.V.V., Piassetta, A.S., Genario, R., Bonan, C.D., Piato, A., Barcellos, L.J.G., de Abreu, M.S. (2019) Tryptophan alleviates neuroendocrine and behavioral responses to stress in zebrafish. Behavioural brain research. 378:112264.
Abstract
Stressful experiences are related to the triggering of anxiety and mood disorders. Tryptophan (amino acid precursor of serotonin synthesis) emerges as important treatment of these disorders. Here, we evaluate the effects of pre-treatment with tryptophan (300 mg/L) and fluoxetine (50 μg/L) in response to acute stress in zebrafish. Overall, acute stress decreased the distance traveled, entries and time in top of tank, as well as increased the cortisol levels, demonstrating an anxiogenic behavior. Tryptophan and fluoxetine prevented anxiogenic effects. This study showed the importance of tryptophan and fluoxetine in the regulation of stress and anxiety-like behavior in adult zebrafish. Collectively, our data support tryptophan effects on stress responses in zebrafish and reinforce the growing utility of this aquatic model to screen CNS therapies.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping