PUBLICATION
A Two-Photon H2 O2 -Activated CO Photoreleaser
- Authors
- Li, Y., Shu, Y., Liang, M., Xie, X., Jiao, X., Wang, X., Tang, B.
- ID
- ZDB-PUB-190911-16
- Date
- 2018
- Source
- Angewandte Chemie (International ed. in English) 57: 12415-12419 (Journal)
- Registered Authors
- Keywords
- carbon monoxide, fluorescence imaging, oxidative stress, two-photon control, vasodilatation
- MeSH Terms
-
- Acetylcysteine/pharmacology
- Angiotensin II/pharmacology
- Animals
- Borates/chemistry
- Carbon Monoxide/chemistry
- Carbon Monoxide/metabolism*
- Flavonoids/chemistry
- Fluorescent Dyes/chemistry
- Hydrogen Peroxide/chemistry*
- Lasers
- Muscle, Smooth, Vascular/cytology
- Muscle, Smooth, Vascular/drug effects
- Muscle, Smooth, Vascular/metabolism
- Photolysis
- Photons
- Spectrometry, Fluorescence
- Zebrafish/metabolism
- PubMed
- 30047607 Full text @ Angew. Chem. Int. Ed. Engl.
Citation
Li, Y., Shu, Y., Liang, M., Xie, X., Jiao, X., Wang, X., Tang, B. (2018) A Two-Photon H2 O2 -Activated CO Photoreleaser. Angewandte Chemie (International ed. in English). 57:12415-12419.
Abstract
Carbon monoxide (CO) is proposed as an active pharmaceutical agent with promising pharmaceutical prospects, as it has been involved in multifaceted modulation of diverse physiological and pathological processes. However, questions remain for therapeutic application of inhaled CO attributed to the inherent great affinity between CO and hemoglobin. Therefore, a robust platform with the function of CO transport and controllable release, depending on the local status of an organism, is of prominent significance for effectively avoiding the side effects of CO inhalation and optimizing the biological regulation function of CO. Utilizing the oxidative stress biomarker H2 O2 as a trigger and combining with photo-control, a two-photon H2 O2 -activated CO photoreleaser, FB, featuring highly sensitive and specific H2 O2 sensing and photocontrollable CO release, was developed and the vasodilation effect of CO against angiotensin II was demonstrated.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping