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ZFIN ID: ZDB-PUB-190820-5
Looking to the future of zebrafish as a model to understand the genetic basis of eye disease
Cavodeassi, F., Wilson, S.W.
Date: 2019
Source: Human genetics   138(8-9): 993-1000 (Other)
Registered Authors: Cavodeassi, Florencia, Wilson, Steve
Keywords: none
MeSH Terms:
  • Animals
  • Coloboma/genetics
  • Eye Diseases/genetics*
  • Humans
  • Microphthalmos/genetics
  • Zebrafish/genetics*
PubMed: 31422478 Full text @ Hum. Genet.
In this brief commentary, we provide some of our thoughts and opinions on the current and future use of zebrafish to model human eye disease, dissect pathological progression and advance in our understanding of the genetic bases of microphthalmia, andophthalmia and coloboma (MAC) in humans. We provide some background on eye formation in fish and conservation and divergence across vertebrates in this process, discuss different approaches for manipulating gene function and speculate on future research areas where we think research using fish may prove to be particularly effective.