PUBLICATION
Circulating tumor cells exit circulation while maintaining multicellularity augmenting metastatic potential
- Authors
- Allen, T.A., Asad, D., Amu, E., Hensley, M.T., Cores, J., Vandergriff, A., Tang, J., Dinh, P.U., Shen, D., Qiao, L., Su, T., Hu, S., Liang, H., Shive, H., Harrell, E., Campbell, C., Peng, X., Yoder, J.A., Cheng, K.
- ID
- ZDB-PUB-190815-1
- Date
- 2019
- Source
- Journal of Cell Science 132(17): (Journal)
- Registered Authors
- Yoder, Jeffrey A.
- Keywords
- Angiopellosis, Cancer exodus hypothesis, Circulating tumor cell cluster, Metastasis, Tumor cell extravasation
- MeSH Terms
-
- Animals
- Cell Count
- Cell Movement/physiology*
- HeLa Cells
- Humans
- Mice
- Neoplasm Metastasis
- Neoplastic Cells, Circulating/metabolism*
- PubMed
- 31409692 Full text @ J. Cell Sci.
Citation
Allen, T.A., Asad, D., Amu, E., Hensley, M.T., Cores, J., Vandergriff, A., Tang, J., Dinh, P.U., Shen, D., Qiao, L., Su, T., Hu, S., Liang, H., Shive, H., Harrell, E., Campbell, C., Peng, X., Yoder, J.A., Cheng, K. (2019) Circulating tumor cells exit circulation while maintaining multicellularity augmenting metastatic potential. Journal of Cell Science. 132(17):.
Abstract
Metastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood. A pivotal step in the metastasis process is the exiting of tumor cells from the circulation, a process known as extravasation. However, it is unclear how tumor cells extravasate, and if multicellular clusters of tumor cells possess the ability to exit as a whole or must first disassociate. In this study, we use in vivo zebrafish and mouse models to elucidate the mechanism tumor cells use to extravasate. We found that circulating tumor cells exit the circulation using the recently identified extravasation mechanism, angiopellosis, and do as both clusters and individual cells. We further show that when melanoma and cervical cancer cells utilize this extravasation method to exit as clusters, they exhibit an increased ability to form tumor at distant sites through the expression of unique genetic profiles. Collectively, we present a new model for tumor cell extravasation of both individual and multicellular circulating tumor cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping