PUBLICATION
Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution
- Authors
- He, Z., Crenshaw, E., Raper, J.A.
- ID
- ZDB-PUB-190729-12
- Date
- 2019
- Source
- Biochemical and Biophysical Research Communications 517(1): 23-28 (Journal)
- Registered Authors
- Raper, Jonathan
- Keywords
- Axonal guidance, Evolutionary conservation, Neuropilins, Semaphorins
- MeSH Terms
-
- Animals
- Biological Evolution
- Humans
- Mice
- Neuropilins/genetics
- Neuropilins/metabolism*
- Phylogeny
- Protein Binding
- Semaphorins/genetics
- Semaphorins/metabolism*
- Species Specificity
- Zebrafish
- PubMed
- 31349972 Full text @ Biochem. Biophys. Res. Commun.
Citation
He, Z., Crenshaw, E., Raper, J.A. (2019) Semaphorin/neuropilin binding specificities are stable over 400 million years of evolution. Biochemical and Biophysical Research Communications. 517(1):23-28.
Abstract
Semaphorins are a large and important family of signaling molecules conserved in Bilateria. An important determinant of the biological function of their largest class, the secreted class 3 semaphorins, is the specificity of their binding to neuropilins, a key component of a larger holoreceptor complex. We compared these binding specificities in mice and zebrafish, species whose most recent common ancestor was more than 400 million years in the past. We also compared the binding specificities of zebrafish class 3 semaphorins that were duplicated very early within the teleost lineage. We found a surprising conservation of neuropilin binding specificities when comparing both paralogous zebrafish semaphorin pairs and orthologous zebrafish and mouse semaphorin pairs. This finding was further supported by a remarkable conservation of binding specificities in cross-species pairings of semaphorins and neuropilins. Our results suggest that the qualitative specificities with which particular semaphorins bind to particular neuropilins has remained nearly invariant over approximately 400 million years of evolution.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping