PUBLICATION
Organization of Embryonic Morphogenesis via Mechanical Information
- Authors
- Das, D., Jülich, D., Schwendinger-Schreck, J., Guillon, E., Lawton, A.K., Dray, N., Emonet, T., O'Hern, C.S., Shattuck, M.D., Holley, S.A.
- ID
- ZDB-PUB-190611-4
- Date
- 2019
- Source
- Developmental Cell 49(6): 829-839.e5 (Journal)
- Registered Authors
- Dray, Nicolas, Holley, Scott, Jülich, Dörthe
- Keywords
- BMP, biomechanics, cell migration, computational modeling, embryonic organizer, eve1, morphogen, morphogenesis, systems biology, tail organizer
- MeSH Terms
-
- Animals
- Body Patterning
- Cell Movement*
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/physiology*
- Embryonic Development*
- Mechanical Phenomena
- Organizers, Embryonic/growth & development*
- Organizers, Embryonic/metabolism
- Signal Transduction
- Zebrafish/embryology*
- Zebrafish Proteins/metabolism*
- PubMed
- 31178400 Full text @ Dev. Cell
Citation
Das, D., Jülich, D., Schwendinger-Schreck, J., Guillon, E., Lawton, A.K., Dray, N., Emonet, T., O'Hern, C.S., Shattuck, M.D., Holley, S.A. (2019) Organization of Embryonic Morphogenesis via Mechanical Information. Developmental Cell. 49(6):829-839.e5.
Abstract
Embryonic organizers establish gradients of diffusible signaling molecules to pattern the surrounding cells. Here, we elucidate an additional mechanism of embryonic organizers that is a secondary consequence of morphogen signaling. Using pharmacological and localized transgenic perturbations, 4D imaging of the zebrafish embryo, systematic analysis of cell motion, and computational modeling, we find that the vertebrate tail organizer orchestrates morphogenesis over distances beyond the range of morphogen signaling. The organizer regulates the rate and coherence of cell motion in the elongating embryo using mechanical information that is transmitted via relay between neighboring cells. This mechanism is similar to a pressure front in granular media and other jammed systems, but in the embryo the mechanical information emerges from self-propelled cell movement and not force transfer between cells. The propagation likely relies upon local biochemical signaling that affects cell contractility, cell adhesion, and/or cell polarity but is independent of transcription and translation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping