PUBLICATION
The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells
- Authors
- Li, Z., He, S., Look, A.T.
- ID
- ZDB-PUB-190601-20
- Date
- 2019
- Source
- Leukemia 33: 262-266 (Other)
- Registered Authors
- He, Shuning, Li, Zhaodong, Look, A. Thomas
- Keywords
- none
- MeSH Terms
-
- Animals
- Antineoplastic Combined Chemotherapy Protocols/therapeutic use*
- Bridged Bicyclo Compounds, Heterocyclic/administration & dosage
- Drug Synergism*
- Embryo, Nonmammalian/drug effects
- Embryo, Nonmammalian/metabolism
- Embryo, Nonmammalian/pathology*
- Humans
- Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors*
- Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
- Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism
- Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology*
- Pyrimidines/administration & dosage
- Sulfonamides/administration & dosage
- T-Lymphocytes/drug effects
- T-Lymphocytes/metabolism
- T-Lymphocytes/pathology*
- Thiophenes/administration & dosage
- Tumor Cells, Cultured
- Zebrafish
- PubMed
- 30008477 Full text @ Leukemia
Citation
Li, Z., He, S., Look, A.T. (2019) The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells. Leukemia. 33:262-266.
Abstract
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping