PUBLICATION

In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway

Authors
Feng, C.W., Chen, N.F., Wen, Z.H., Yang, W.Y., Kuo, H.M., Sung, P.J., Su, J.H., Cheng, S.Y., Chen, W.F.
ID
ZDB-PUB-190601-12
Date
2019
Source
Marine drugs   17(6): (Journal)
Registered Authors
Keywords
HO-1, Nrf2, Parkinson?s disease, apoptosis, oxidative stress, sponge-derived compound
MeSH Terms
  • NF-E2-Related Factor 2/metabolism*
  • Humans
  • Porifera/chemistry*
  • Animals
  • Heme Oxygenase-1/metabolism*
  • Triterpenes/chemistry
  • Triterpenes/isolation & purification
  • Triterpenes/pharmacology*
  • Cell Line
  • Cell Survival/drug effects
  • Disease Models, Animal
  • Aquatic Organisms/chemistry
  • Locomotion/drug effects
  • Parkinson Disease/drug therapy
  • Apoptosis/drug effects*
  • Oxidative Stress/drug effects*
  • Neuroprotective Agents/pharmacology
  • Zebrafish
  • Oxidopamine/toxicity
(all 19)
PubMed
31146323 Full text @ Mar. Drugs
Abstract
Pharmaceutical agents for halting the progression of Parkinson's disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated the neuroprotective activity of stellettin B (SB), a compound isolated from marine sponges. We showed that SB could significantly protect SH-SY5Y cells against 6-OHDA-induced cellular damage by inhibiting cell apoptosis and oxidative stress through PI3K/Akt, MAPK, caspase cascade modulation and Nrf2/HO-1 cascade modulation, respectively. In addition, an in vivo study showed that SB reversed 6-OHDA-induced a locomotor deficit in a zebrafish model of PD. The potential for developing SB as a candidate drug for PD treatment is discussed.
Genes / Markers
Figures
Figure Gallery (4 images)
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Expression
Phenotype
Fish Conditions Stage Phenotype Figure
WTchemical treatment by environment: oxidopamineDays 7-13
WTchemical treatment by environment: triterpenoid, chemical treatment by environment: oxidopamineDays 7-13
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Mutations / Transgenics
No data available
Human Disease / Model
Human Disease Fish Conditions Evidence
Parkinson's diseaseWTchemical treatment by environment: oxidopamineTAS
1 - 1 of 1
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Sequence Targeting Reagents
No data available
Fish
Fish
WT
1 - 1 of 1
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Antibodies
Orthology
Engineered Foreign Genes
No data available
Mapping
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Citation
Feng, C.W., Chen, N.F., Wen, Z.H., Yang, W.Y., Kuo, H.M., Sung, P.J., Su, J.H., Cheng, S.Y., Chen, W.F. (2019) In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway. Marine drugs. 17(6).