PUBLICATION

Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo

Authors
Krasnow, A.M., Ford, M.C., Valdivia, L.E., Wilson, S.W., Attwell, D.
ID
ZDB-PUB-190510-18
Date
2018
Source
Nature Neuroscience   21: 24-28 (Other)
Registered Authors
Krasnow, Anna, Valdivia, Leonardo, Wilson, Steve
Keywords
none
MeSH Terms
  • Action Potentials/drug effects
  • Action Potentials/genetics
  • Animals
  • Animals, Genetically Modified
  • Axons/drug effects
  • Axons/physiology*
  • Calcium/metabolism*
  • Calcium/pharmacology
  • Chelating Agents/pharmacology
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Egtazic Acid/analogs & derivatives
  • Egtazic Acid/pharmacology
  • Luminescent Proteins/genetics
  • Luminescent Proteins/metabolism
  • Mivacurium/pharmacology
  • Myelin Basic Protein/genetics
  • Myelin Basic Protein/metabolism
  • Myelin Sheath/physiology*
  • Neuromuscular Nondepolarizing Agents/pharmacology
  • Neurons/drug effects
  • Neurons/physiology*
  • Oligodendroglia/physiology*
  • SOXE Transcription Factors/genetics
  • SOXE Transcription Factors/metabolism
  • Sodium Channel Blockers/pharmacology
  • Spinal Cord/cytology
  • Tetrodotoxin/pharmacology
  • Zebrafish
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed
29230052 Full text @ Nat. Neurosci.
Abstract
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+]i in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+]i transients and prevented by [Ca2+]i buffering. Sheath elongation occurs ~1 h after [Ca2+]i elevation. Sheath shortening is associated with a low frequency of [Ca2+]i transients but with longer duration [Ca2+]i bursts. Thus, [Ca2+]i controls myelin sheath development.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping