PUBLICATION

The Body Size of Stimulus Conspecifics Affects Social Preference in a Binary Choice Task in Wild-Type, But Not in dyrk1aa Mutant, Zebrafish

Authors
Aslanzadeh, M., Ariyasiri, K., Kim, O.H., Choi, T.I., Lim, J.H., Kim, H.G., Gerlai, R., Kim, C.H.
ID
ZDB-PUB-190507-46
Date
2019
Source
Zebrafish   16(3): 262-267 (Journal)
Registered Authors
Gerlai, Robert T., Kim, Cheol-Hee
Keywords
, autism spectrum disorders, shoaling, social behavior, social preference task
MeSH Terms
  • Animals
  • Body Size*
  • Male
  • Photic Stimulation
  • Social Behavior*
  • Zebrafish/genetics
  • Zebrafish/physiology*
PubMed
31058587 Full text @ Zebrafish
Abstract
The zebrafish has become an appropriate animal model in the analysis of numerous human brain disorders. A variety of neuropsychiatric conditions and neurodevelopmental disorders are comorbid with abnormal social behavior. Given the translational relevance of zebrafish, multidisciplinary studies employing behavioral, neurobiological, and molecular methods with this species may provide insights into human central nervous system (CNS) disorders. Many of these studies impinge upon our ability to properly induce and quantify the behavior of zebrafish, a relatively understudied aspect of this species. In this study, we investigate how the body size of conspecifics relative to that of the test subject influences social (shoaling) responses in zebrafish. We found a robust preference by wild-type (WT) test zebrafish toward big conspecifics, but not toward smaller conspecifics. Additionally, we tested an autism-relevant zebrafish knockout (KO) model. The dyrk1aa KO zebrafish showed impaired social preference compared with WT in the social behavior test. Our results confirm the effect of relative body size on social preference and that the social preference task developed for zebrafish may uncover the function of genes and biological mechanisms potentially associated with human CNS disorders.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes