PUBLICATION
A Retinal Circuit Generating a Dynamic Predictive Code for Oriented Features
- Authors
- Johnston, J., Seibel, S.H., Darnet, L.S.A., Renninger, S., Orger, M., Lagnado, L.
- ID
- ZDB-PUB-190507-37
- Date
- 2019
- Source
- Neuron 102(6): 1211-1222.e3 (Journal)
- Registered Authors
- Darnet, Léa, Lagnado, Leon, Orger, Mike, Renninger, Sabine, Seibel, Sofie-Helene
- Keywords
- orientation, predictive code, retina, synapse, tectum, vision, zebrafish
- MeSH Terms
-
- Animals
- Escherichia coli Proteins
- Glutamic Acid/metabolism
- Green Fluorescent Proteins
- Larva
- Neural Inhibition/physiology*
- Optical Imaging
- Orientation, Spatial
- Recombinant Fusion Proteins
- Retina
- Retinal Bipolar Cells/metabolism
- Retinal Bipolar Cells/physiology*
- Retinal Ganglion Cells/metabolism
- Retinal Ganglion Cells/physiology*
- Space Perception/physiology*
- Synapses/metabolism
- Synapses/physiology*
- Vision, Ocular/physiology*
- Visual Pathways
- Zebrafish
- PubMed
- 31054873 Full text @ Neuron
Citation
Johnston, J., Seibel, S.H., Darnet, L.S.A., Renninger, S., Orger, M., Lagnado, L. (2019) A Retinal Circuit Generating a Dynamic Predictive Code for Oriented Features. Neuron. 102(6):1211-1222.e3.
Abstract
Sensory systems must reduce the transmission of redundant information to function efficiently. One strategy is to continuously adjust the sensitivity of neurons to suppress responses to common features of the input while enhancing responses to new ones. Here we image the excitatory synaptic inputs and outputs of retinal ganglion cells to understand how such dynamic predictive coding is implemented in the analysis of spatial patterns. Synapses of bipolar cells become tuned to orientation through presynaptic inhibition, generating lateral antagonism in the orientation domain. Individual ganglion cells receive excitatory synapses tuned to different orientations, but feedforward inhibition generates a high-pass filter that only transmits the initial activation of these inputs, removing redundancy. These results demonstrate how a dynamic predictive code can be implemented by circuit motifs common to many parts of the brain.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping