ZFIN ID: ZDB-PUB-190507-37
A Retinal Circuit Generating a Dynamic Predictive Code for Oriented Features
Johnston, J., Seibel, S.H., Darnet, L.S.A., Renninger, S., Orger, M., Lagnado, L.
Date: 2019
Source: Neuron   102(6): 1211-1222.e3 (Journal)
Registered Authors: Darnet, Léa, Lagnado, Leon, Orger, Mike, Renninger, Sabine, Seibel, Sofie-Helene
Keywords: orientation, predictive code, retina, synapse, tectum, vision, zebrafish
MeSH Terms:
  • Animals
  • Escherichia coli Proteins
  • Glutamic Acid/metabolism
  • Green Fluorescent Proteins
  • Larva
  • Neural Inhibition/physiology*
  • Optical Imaging
  • Orientation, Spatial
  • Recombinant Fusion Proteins
  • Retina
  • Retinal Bipolar Cells/metabolism
  • Retinal Bipolar Cells/physiology*
  • Retinal Ganglion Cells/metabolism
  • Retinal Ganglion Cells/physiology*
  • Space Perception/physiology*
  • Synapses/metabolism
  • Synapses/physiology*
  • Vision, Ocular/physiology*
  • Visual Pathways
  • Zebrafish
PubMed: 31054873 Full text @ Neuron
Sensory systems must reduce the transmission of redundant information to function efficiently. One strategy is to continuously adjust the sensitivity of neurons to suppress responses to common features of the input while enhancing responses to new ones. Here we image the excitatory synaptic inputs and outputs of retinal ganglion cells to understand how such dynamic predictive coding is implemented in the analysis of spatial patterns. Synapses of bipolar cells become tuned to orientation through presynaptic inhibition, generating lateral antagonism in the orientation domain. Individual ganglion cells receive excitatory synapses tuned to different orientations, but feedforward inhibition generates a high-pass filter that only transmits the initial activation of these inputs, removing redundancy. These results demonstrate how a dynamic predictive code can be implemented by circuit motifs common to many parts of the brain.