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ZFIN ID: ZDB-PUB-190430-1
Neuronal Dynamics Regulating Brain and Behavioral State Transitions
Andalman, A.S., Burns, V.M., Lovett-Barron, M., Broxton, M., Poole, B., Yang, S.J., Grosenick, L., Lerner, T.N., Chen, R., Benster, T., Mourrain, P., Levoy, M., Rajan, K., Deisseroth, K.
Date: 2019
Source: Cell   177(4): 970-985.e20 (Journal)
Registered Authors: Mourrain, Philippe
Keywords: none
MeSH Terms:
  • Adaptation, Psychological/physiology*
  • Animals
  • Behavior, Animal/physiology
  • Brain/metabolism
  • Habenula/metabolism
  • Habenula/physiology*
  • Larva
  • Neural Pathways/metabolism
  • Neurons/metabolism
  • Raphe Nuclei/metabolism
  • Serotonergic Neurons/metabolism
  • Serotonin
  • Stress, Physiological/physiology
  • Zebrafish/metabolism
  • Zebrafish Proteins/metabolism
PubMed: 31031000 Full text @ Cell
Prolonged behavioral challenges can cause animals to switch from active to passive coping strategies to manage effort-expenditure during stress; such normally adaptive behavioral state transitions can become maladaptive in psychiatric disorders such as depression. The underlying neuronal dynamics and brainwide interactions important for passive coping have remained unclear. Here, we develop a paradigm to study these behavioral state transitions at cellular-resolution across the entire vertebrate brain. Using brainwide imaging in zebrafish, we observed that the transition to passive coping is manifested by progressive activation of neurons in the ventral (lateral) habenula. Activation of these ventral-habenula neurons suppressed downstream neurons in the serotonergic raphe nucleus and caused behavioral passivity, whereas inhibition of these neurons prevented passivity. Data-driven recurrent neural network modeling pointed to altered intra-habenula interactions as a contributory mechanism. These results demonstrate ongoing encoding of experience features in the habenula, which guides recruitment of downstream networks and imposes a passive coping behavioral strategy.