PUBLICATION
Neuronal Dynamics Regulating Brain and Behavioral State Transitions
- Authors
- Andalman, A.S., Burns, V.M., Lovett-Barron, M., Broxton, M., Poole, B., Yang, S.J., Grosenick, L., Lerner, T.N., Chen, R., Benster, T., Mourrain, P., Levoy, M., Rajan, K., Deisseroth, K.
- ID
- ZDB-PUB-190430-1
- Date
- 2019
- Source
- Cell 177(4): 970-985.e20 (Journal)
- Registered Authors
- Mourrain, Philippe
- Keywords
- none
- MeSH Terms
-
- Adaptation, Psychological/physiology*
- Animals
- Behavior, Animal/physiology
- Brain/metabolism
- Habenula/metabolism
- Habenula/physiology*
- Larva
- Neural Pathways/metabolism
- Neurons/metabolism
- Raphe Nuclei/metabolism
- Serotonergic Neurons/metabolism
- Serotonin
- Stress, Physiological/physiology
- Zebrafish/metabolism
- Zebrafish Proteins/metabolism
- PubMed
- 31031000 Full text @ Cell
Citation
Andalman, A.S., Burns, V.M., Lovett-Barron, M., Broxton, M., Poole, B., Yang, S.J., Grosenick, L., Lerner, T.N., Chen, R., Benster, T., Mourrain, P., Levoy, M., Rajan, K., Deisseroth, K. (2019) Neuronal Dynamics Regulating Brain and Behavioral State Transitions. Cell. 177(4):970-985.e20.
Abstract
Prolonged behavioral challenges can cause animals to switch from active to passive coping strategies to manage effort-expenditure during stress; such normally adaptive behavioral state transitions can become maladaptive in psychiatric disorders such as depression. The underlying neuronal dynamics and brainwide interactions important for passive coping have remained unclear. Here, we develop a paradigm to study these behavioral state transitions at cellular-resolution across the entire vertebrate brain. Using brainwide imaging in zebrafish, we observed that the transition to passive coping is manifested by progressive activation of neurons in the ventral (lateral) habenula. Activation of these ventral-habenula neurons suppressed downstream neurons in the serotonergic raphe nucleus and caused behavioral passivity, whereas inhibition of these neurons prevented passivity. Data-driven recurrent neural network modeling pointed to altered intra-habenula interactions as a contributory mechanism. These results demonstrate ongoing encoding of experience features in the habenula, which guides recruitment of downstream networks and imposes a passive coping behavioral strategy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping