PUBLICATION
Lipid Modulating Anti-oxidant Stress Activity of Gastrodin on Nonalcoholic Fatty Liver Disease Larval Zebrafish Model
- Authors
- Ahmad, O., Wang, B., Ma, K., Deng, Y., Li, M., Yang, L., Yang, Y., Zhao, J., Cheng, L., Zhou, Q., Shang, J.
- ID
- ZDB-PUB-190426-1
- Date
- 2019
- Source
- International Journal of Molecular Sciences 20(8): (Journal)
- Registered Authors
- Li, Maoru, Shang, Jing, Wang, Bing
- Keywords
- Gastrodin, larval zebrafish, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis
- MeSH Terms
-
- Animals
- Antioxidants/isolation & purification
- Antioxidants/therapeutic use*
- Benzyl Alcohols/isolation & purification
- Benzyl Alcohols/therapeutic use*
- Disease Models, Animal
- Gastrodia/chemistry*
- Gene Expression Regulation/drug effects
- Glucosides/isolation & purification
- Glucosides/therapeutic use*
- Larva/drug effects
- Larva/genetics
- Larva/metabolism
- Lipid Metabolism/drug effects*
- Non-alcoholic Fatty Liver Disease/drug therapy*
- Non-alcoholic Fatty Liver Disease/genetics
- Non-alcoholic Fatty Liver Disease/metabolism
- Non-alcoholic Fatty Liver Disease/pathology
- Zebrafish/genetics
- Zebrafish/metabolism
- PubMed
- 31018538 Full text @ Int. J. Mol. Sci.
Citation
Ahmad, O., Wang, B., Ma, K., Deng, Y., Li, M., Yang, L., Yang, Y., Zhao, J., Cheng, L., Zhou, Q., Shang, J. (2019) Lipid Modulating Anti-oxidant Stress Activity of Gastrodin on Nonalcoholic Fatty Liver Disease Larval Zebrafish Model. International Journal of Molecular Sciences. 20(8).
Abstract
Non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the world. However, there are still no drugs for NAFLD/NASH in the market. Gastrodin (GAS) is a bioactive compound that is extracted from Gastrodia elata, which is used as an active compound on nervous system diseases. Recent reports showed that GAS and Gastrodia elata possess anti-oxidant activity and lipid regulating effects, which makes us curious to reveal the anti-NAFLD effect of GAS. A high cholesterol diet (HCD) was used to induce a NAFLD larval zebrafish model, and the lipid regulation and anti-oxidant effects were tested on the model. Furthermore, qRT-PCR studied the underlying mechanism of GAS. To conclude, this study revealed a lipid regulation and anti-oxidant insights of GAS on NAFLD larval zebrafish model and provided a potential therapeutic compound for NAFLD treatment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping