PUBLICATION

Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders

Authors
Zabegalov, K.N., Khatsko, S.L., Lakstyga, A.M., Demin, K.A., Cleal, M., Fontana, B.D., McBride, S.D., Harvey, B.H., de Abreu, M.S., Parker, M.O., Kalueff, A.V.
ID
ZDB-PUB-190331-6
Date
2019
Source
Behavioural brain research   367: 101-110 (Other)
Registered Authors
Kalueff, Allan V.
Keywords
abnormal repetitive behavior, animal models, human brain disorders, stereotypy, zebrafish
MeSH Terms
  • Animals
  • Behavior, Animal/physiology*
  • Cognitive Dysfunction/genetics
  • Cognitive Dysfunction/physiopathology*
  • Disease Models, Animal*
  • Executive Function/physiology*
  • Humans
  • Neurodevelopmental Disorders/genetics
  • Neurodevelopmental Disorders/physiopathology*
  • Obsessive-Compulsive Disorder/genetics
  • Obsessive-Compulsive Disorder/physiopathology*
  • Stereotypic Movement Disorder/genetics
  • Stereotypic Movement Disorder/physiopathology*
  • Zebrafish/physiology*
PubMed
30926483 Full text @ Behav. Brain Res.
Abstract
Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models. As rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to practical research advantages, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and stereotypic behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanisms.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping