PUBLICATION
Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
- Authors
- Zabegalov, K.N., Khatsko, S.L., Lakstyga, A.M., Demin, K.A., Cleal, M., Fontana, B.D., McBride, S.D., Harvey, B.H., de Abreu, M.S., Parker, M.O., Kalueff, A.V.
- ID
- ZDB-PUB-190331-6
- Date
- 2019
- Source
- Behavioural brain research 367: 101-110 (Other)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- abnormal repetitive behavior, animal models, human brain disorders, stereotypy, zebrafish
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology*
- Cognitive Dysfunction/genetics
- Cognitive Dysfunction/physiopathology*
- Disease Models, Animal*
- Executive Function/physiology*
- Humans
- Neurodevelopmental Disorders/genetics
- Neurodevelopmental Disorders/physiopathology*
- Obsessive-Compulsive Disorder/genetics
- Obsessive-Compulsive Disorder/physiopathology*
- Stereotypic Movement Disorder/genetics
- Stereotypic Movement Disorder/physiopathology*
- Zebrafish/physiology*
- PubMed
- 30926483 Full text @ Behav. Brain Res.
Citation
Zabegalov, K.N., Khatsko, S.L., Lakstyga, A.M., Demin, K.A., Cleal, M., Fontana, B.D., McBride, S.D., Harvey, B.H., de Abreu, M.S., Parker, M.O., Kalueff, A.V. (2019) Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders. Behavioural brain research. 367:101-110.
Abstract
Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models. As rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to practical research advantages, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and stereotypic behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanisms.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping