ZFIN ID: ZDB-PUB-190331-5
Effects of sex hormones on liver tumor progression and regression in Myc/xmrk double oncogene transgenic zebrafish
Li, H., Lu, J.W., Huo, X., Li, Y., Li, Z., Gong, Z.
Date: 2019
Source: General and comparative endocrinology   277: 112-121 (Journal)
Registered Authors: Gong, Zhiyuan, Li, Zhen
Keywords: 11-ketotestosterone (KT11), 17β-estradiol (E2), Hepatocellular carcinoma, Liver cancer, Sex hormones, Zebrafish
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Carcinoma, Hepatocellular/pathology
  • Cell Proliferation/drug effects
  • Disease Progression*
  • Female
  • Gonadal Steroid Hormones/pharmacology*
  • Liver Neoplasms/pathology*
  • Male
  • Oncogenes*
  • Sex Characteristics
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 30926469 Full text @ Gen. Comp. Endocrinol.
Hepatocellular carcinoma (HCC) shows clear sex disparity with men being more prone to developing HCC and having higher mortality than women. Previous studies have indicated that sex hormones play important roles in HCC initiation and development, but the effects of sex hormones on HCC in clinical trials remain inconsistent. Using zebrafish liver tumor model co-induced by oncogenes Myc and xmrk, we observed similar sex disparity between male and female zebrafish in liver tumor progression and regression; i.e. male Myc/xmrk transgenic zebrafish developed HCC significantly faster and regressed HCC significantly slower than female Myc/xmrk transgenic zebrtafish. To investigate the effects of sex hormones on liver tumor progression and regression, Myc/xmrk fish were treated with either androgen or estrogen, we observed that androgen promoted HCC progression and retarded HCC regression in females, while estrogen attenuated HCC progression and accelerated HCC regression in males. Furthermore, androgen promoted cell proliferation while estrogen inhibited it. Overall, the present study suggested that sex hormones affected liver tumor progression and regression in the Myc/xmrk transgenic zebrafish.