PUBLICATION
The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain
- Authors
- Cox, J.A., Voigt, M.M.
- ID
- ZDB-PUB-190322-6
- Date
- 2019
- Source
- Frontiers in neural circuits 13: 14 (Journal)
- Registered Authors
- Cox, Jane, Voigt, Mark
- Keywords
- axon guidance, cranial nerves, metalloprotease, sensory circuits, zebrafish
- MeSH Terms
-
- Axon Guidance/genetics
- Axon Guidance/physiology*
- Animals
- Rhombencephalon/cytology*
- Rhombencephalon/physiology*
- Mutation/genetics
- Larva
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Clustered Regularly Interspaced Short Palindromic Repeats
- Ganglia, Invertebrate/cytology
- Embryo, Nonmammalian
- Zebrafish
- ADAM Proteins/genetics
- ADAM Proteins/metabolism*
- Gene Expression Regulation, Developmental/physiology
- DNA Mutational Analysis
- Green Fluorescent Proteins/genetics
- Green Fluorescent Proteins/metabolism
- Animals, Genetically Modified
- Sensory Receptor Cells/metabolism*
- Receptors, Purinergic P2/genetics
- Receptors, Purinergic P2/metabolism
- CRISPR-Associated Protein 9/genetics
- CRISPR-Associated Protein 9/metabolism
- PubMed
- 30894803 Full text @ Front. Neural Circuits
Citation
Cox, J.A., Voigt, M.M. (2019) The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain. Frontiers in neural circuits. 13:14.
Abstract
Little is known about the molecular and cellular mechanisms involved in the formation of the cranial peripheral sensory system in vertebrates. To identify genes involved in the formation of these circuits, we performed a forward genetic screen utilizing a transgenic zebrafish line (p2rx3.2:gfpsl1) that expresses green fluorescent protein (gfp) in sensory neurons of the Vth, VIIth, IXth and Xth cranial ganglia. Here, we describe a novel zebrafish mutant in which a missense mutation in the adam19b gene selectively affects the epibranchial sensory circuits.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping