PUBLICATION
In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish
- Authors
- Qiu, W., Fang, M., Liu, J., Fu, C., Zheng, C., Chen, B., Wang, K.J.
- ID
- ZDB-PUB-190322-1
- Date
- 2019
- Source
- The Science of the total environment 665: 995-1002 (Journal)
- Registered Authors
- Keywords
- Bisphenol F, Enzyme aromatase pathways, Estrogen receptor, Reproductive neuroendocrine system, Zebrafish
- MeSH Terms
-
- Animals
- Benzhydryl Compounds/toxicity*
- Dose-Response Relationship, Drug
- Female
- Male
- Neurosecretory Systems/drug effects*
- Phenols/toxicity*
- Random Allocation
- Reproduction/drug effects*
- Water Pollutants, Chemical/toxicity*
- Zebrafish/physiology*
- PubMed
- 30893755 Full text @ Sci. Total Environ.
- CTD
- 30893755
Citation
Qiu, W., Fang, M., Liu, J., Fu, C., Zheng, C., Chen, B., Wang, K.J. (2019) In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish. The Science of the total environment. 665:995-1002.
Abstract
Although Bisphenol F (BPF), a bisphenol A (BPA) analogue with a similar chemical structure to that of BPA, is widely used in commercial products, little is known about its potential toxic effects on the reproductive neuroendocrine system in vivo. The present study aimed to comprehensively evaluate the effects of BPF on the reproductive neuroendocrine system in zebrafish and to assess the potential mechanisms underlying its association with estrogen receptor (ER) and aromatase (AROM) pathways. Long-term exposure to environmentally relevant and low levels of BPF led to increased expression of reproductive neuroendocrine-related genes (kiss1, kiss1r, gnrh3, lhβ, and fshβ) in the zebrafish brain, as well as increased levels of adrenocorticotropic, gonadotropin-releasing, luteinizing, and follicle-stimulating hormones in the zebrafish brain and vitellogenin in the zebrafish liver. In addition, these effects were associated with an increase in erα, erβ, cyp19a, and cyp19b activity. Meanwhile, ER and AROM antagonists, alone or in combination, significantly attenuated the stimulation of kiss1, lhβ, vtg, and gnrh3 expression, thereby suggesting that chronic BPF exposure affects the regulation of the reproductive neuroendocrine system through activation of the ER and AROM pathways. Moreover, since BPF and bisphenol S induced toxic and reproductive neuroendocrine effects similar to those of BPA, the current accepted usage of BPA and its analogs should be reconsidered in the future.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping