PUBLICATION
Zebrafish Models of Neurodevelopmental Disorders: Limitations and Benefits of Current Tools and Techniques
- Authors
- Vaz, R., Hofmeister, W., Lindstrand, A.
- ID
- ZDB-PUB-190317-2
- Date
- 2019
- Source
- International Journal of Molecular Sciences 20(6): (Review)
- Registered Authors
- Vaz, Raquel
- Keywords
- disease models, functional assays, neurodevelopmental disorders, zebrafish
- MeSH Terms
-
- Animals
- Brain/growth & development
- Brain/pathology
- Disease Models, Animal
- Genetic Predisposition to Disease
- Humans
- Neurodevelopmental Disorders/genetics
- Neurodevelopmental Disorders/pathology*
- Phenotype
- Zebrafish*
- PubMed
- 30875831 Full text @ Int. J. Mol. Sci.
Citation
Vaz, R., Hofmeister, W., Lindstrand, A. (2019) Zebrafish Models of Neurodevelopmental Disorders: Limitations and Benefits of Current Tools and Techniques. International Journal of Molecular Sciences. 20(6).
Abstract
For the past few years there has been an exponential increase in the use of animal models to confirm the pathogenicity of candidate disease-causing genetic variants found in patients. One such animal model is the zebrafish. Despite being a non-mammalian animal, the zebrafish model has proven its potential in recapitulating the phenotypes of many different human genetic disorders. This review will focus on recent advances in the modeling of neurodevelopmental disorders in zebrafish, covering aspects from early brain development to techniques used for modulating gene expression, as well as how to best characterize the resulting phenotypes. We also review other existing models of neurodevelopmental disorders, and the current efforts in developing and testing compounds with potential therapeutic value.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping