PUBLICATION

Development of the brain vasculature and the blood-brain barrier in zebrafish

Authors
Quiñonez-Silvero, C., Hübner, K., Herzog, W.
ID
ZDB-PUB-190314-2
Date
2019
Source
Developmental Biology   457(2): 181-190 (Review)
Registered Authors
Herzog, Wiebke
Keywords
Angiogenesis, Central nervous system, Junctions, Neurovascular unit
MeSH Terms
  • Endothelial Cells/physiology
  • Tight Junctions/physiology
  • Brain/blood supply*
  • Brain/embryology
  • Animals
  • Neovascularization, Physiologic/physiology*
  • Cardiovascular System/embryology*
  • Endothelium, Vascular/embryology
  • Endothelium, Vascular/physiology
  • Zebrafish/embryology*
  • Blood-Brain Barrier/embryology*
(all 11)
PubMed
30862465 Full text @ Dev. Biol.
Abstract
To ensure tissue homeostasis the brain needs to be protected from blood-derived fluctuations or pathogens that could affect its function. Therefore, the brain capillaries develop tissue-specific properties to form a selective blood-brain barrier (BBB), allowing the passage of essential molecules to the brain and blocking the penetration of potentially harmful compounds or cells. Previous studies reported the presence of this barrier in zebrafish. The intrinsic features of the zebrafish embryos and larvae in combination with optical techniques, make them suitable for the study of barrier establishment and maturation. In this review, we discuss the most recent contributions to the development and formation of a functional zebrafish BBB. Moreover, we compare the molecular and cellular characteristic of the zebrafish and the mammalian BBB.
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Mutations / Transgenics
Allele Construct Type Affected Genomic Region
mu213TgTransgenic Insertion
    ncv24TgTransgenic Insertion
      nkuasgfp1aTgTransgenic Insertion
        s896TgTransgenic Insertion
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          Engineered Foreign Genes
          Marker Marker Type Name
          EGFPEFGEGFP
          GAL4FFEFGGAL4FF
          mCherryEFGmCherry
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          Citation
          Quiñonez-Silvero, C., Hübner, K., Herzog, W. (2019) Development of the brain vasculature and the blood-brain barrier in zebrafish. Developmental Biology. 457(2):181-190.