PUBLICATION

Distinct progenitor populations mediate regeneration in the zebrafish lateral line

Authors
Thomas, E.D., Raible, D.W.
ID
ZDB-PUB-190306-11
Date
2019
Source
eLIFE   8: (Journal)
Registered Authors
Raible, David
Keywords
developmental biology, regenerative medicine, stem cells, zebrafish
MeSH Terms
  • Animals
  • Cell Proliferation
  • Lateral Line System/injuries*
  • Regeneration*
  • Stem Cells/physiology*
  • Zebrafish*
PubMed
30834891 Full text @ Elife
Abstract
Mechanosensory hair cells of the zebrafish lateral line regenerate rapidly following damage. These renewed hair cells arise from the proliferation of surrounding support cells, which undergo symmetric division to produce two hair cell daughters. Given the continued regenerative capacity of the lateral line, support cells presumably have the ability to replenish themselves. Utilizing novel transgenic lines, we identified support cell populations with distinct progenitor identities. These populations show differences in their ability to generate new hair cells during homeostasis and regeneration. Targeted ablation of support cells reduced the number of regenerated hair cells. Furthermore, progenitors regenerated after targeted support cell ablation in the absence of hair cell damage. We also determined that distinct support cell populations are independently regulated by Notch signaling. The existence of independent progenitor populations could provide flexibility for the continued generation of new hair cells under a variety of conditions throughout the life of the animal.
Genes / Markers
Figures
Figure Gallery
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes