PUBLICATION
The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models
- Authors
- Demin, K.A., Lakstygal, A.M., Alekseeva, P.A., Sysoev, M., de Abreu, M.S., Alpyshov, E.T., Serikuly, N., Wang, D., Wang, M., Tang, Z., Yan, D., Strekalova, T.V., Volgin, A.D., Amstislavskaya, T.G., Wang, J., Song, C., Kalueff, A.V.
- ID
- ZDB-PUB-190302-8
- Date
- 2019
- Source
- Aquatic toxicology (Amsterdam, Netherlands) 210: 44-55 (Other)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Aquatic models, Individuality, Intraspecies variation, Neurobehavioral variation, Zebrafish
- MeSH Terms
-
- Animals
- Behavior, Animal/drug effects*
- Gene-Environment Interaction
- Humans
- Models, Biological
- Nervous System Physiological Phenomena/drug effects*
- Nervous System Physiological Phenomena/genetics
- Phenotype
- Reproducibility of Results
- Sex Characteristics
- Species Specificity
- Water Pollutants, Chemical/toxicity*
- Zebrafish/genetics
- Zebrafish/physiology*
- PubMed
- 30822702 Full text @ Aquat. Toxicol.
Citation
Demin, K.A., Lakstygal, A.M., Alekseeva, P.A., Sysoev, M., de Abreu, M.S., Alpyshov, E.T., Serikuly, N., Wang, D., Wang, M., Tang, Z., Yan, D., Strekalova, T.V., Volgin, A.D., Amstislavskaya, T.G., Wang, J., Song, C., Kalueff, A.V. (2019) The role of intraspecies variation in fish neurobehavioral and neuropharmacological phenotypes in aquatic models. Aquatic toxicology (Amsterdam, Netherlands). 210:44-55.
Abstract
Intraspecies variation is common in both clinical and animal research of various brain disorders. Relatively well-studied in mammals, intraspecies variation in aquatic fish models and its role in their behavioral and pharmacological responses remain poorly understood. Like humans and mammals, fishes show high variance of behavioral and drug-evoked responses, modulated both genetically and environmentally. The zebrafish (Danio rerio) has emerged as a particularly useful model organism tool to access neurobehavioral and drug-evoked responses. Here, we discuss recent findings and the role of the intraspecies variance in neurobehavioral, pharmacological and toxicological studies utilizing zebrafish and other fish models. We also critically evaluate common sources of intraspecies variation and outline potential strategies to improve data reproducibility and translatability.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping