PUBLICATION
Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy
- Authors
- Wang, S., Wu, W., Manghnani, P., Xu, S., Wang, Y., Goh, C.C., Ng, L.G., Liu, B.
- ID
- ZDB-PUB-190215-14
- Date
- 2019
- Source
- ACS nano 13(3): 3095-3105 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Antineoplastic Agents/chemical synthesis
- Antineoplastic Agents/chemistry
- Antineoplastic Agents/pharmacology*
- Embryo, Nonmammalian/drug effects
- Liver Neoplasms/drug therapy*
- Liver Neoplasms/metabolism
- Photochemotherapy*
- Photons*
- Photosensitivity Disorders
- Photosensitizing Agents/chemical synthesis
- Photosensitizing Agents/chemistry
- Photosensitizing Agents/pharmacology*
- Polymerization
- Precision Medicine*
- Singlet Oxygen/metabolism
- Zebrafish
- PubMed
- 30763072 Full text @ ACS Nano
Citation
Wang, S., Wu, W., Manghnani, P., Xu, S., Wang, Y., Goh, C.C., Ng, L.G., Liu, B. (2019) Polymerization-Enhanced Two-Photon Photosensitization for Precise Photodynamic Therapy. ACS nano. 13(3):3095-3105.
Abstract
Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep tissue and high spatiotemporal precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen (1O2) generation efficiency and large two-photon absorption (2PA) cross section are highly desirable, but the availability of such PSs is limited by challenges in molecular design. In this work, we report that polymerization of small molecule PSs with aggregation-induced emission (AIE) could yield conjugated polymer PSs with good brightness, high 1O2 generation efficiency and large 2PA cross section. Two conjugated polymer PSs were designed and synthesized and the corresponding AIE PS dots were prepared by nanoprecipitation, which exhibited outstanding 2PE-PDT performance in in vitro cancer cell ablation and in vivo zebrafish liver tumor treatment. Our work highlights a strategy to design highly efficient PSs for 2PE-PDT.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping