PUBLICATION
Neuropharmacology, pharmacogenetics and pharmacogenomics of aggression: the zebrafish model
- Authors
- de Abreu, M.S., Giacomini, A.C.V.V., Genario, R., Dos Santos, B.E., da Rosa, L.G., Demin, K.A., Wappler-Guzzetta, E., Kalueff, A.V.
- ID
- ZDB-PUB-190203-5
- Date
- 2019
- Source
- Pharmacological research 141: 602-608 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- CNS, aggression, animal models, epigenetics, pharmacological modulation
- MeSH Terms
-
- Central Nervous System Agents/pharmacology
- Pharmacogenetics
- Neuropharmacology
- Aggression*/drug effects
- Central Nervous System Diseases/drug therapy
- Central Nervous System Diseases/genetics*
- Central Nervous System Diseases/pathology
- Translational Research, Biomedical
- Disease Models, Animal*
- Animals
- Zebrafish/genetics*
- Zebrafish/physiology
- PubMed
- 30708051 Full text @ Pharmacol. Res.
Citation
de Abreu, M.S., Giacomini, A.C.V.V., Genario, R., Dos Santos, B.E., da Rosa, L.G., Demin, K.A., Wappler-Guzzetta, E., Kalueff, A.V. (2019) Neuropharmacology, pharmacogenetics and pharmacogenomics of aggression: the zebrafish model. Pharmacological research. 141:602-608.
Abstract
The zebrafish (Danio rerio) is increasingly utilized as a powerful new model organism in neurobehavioral research. Aggression is a common symptom of many CNS disorders, has some genetic deterinants and can be modulated pharmacologically in humans and animal model species. Mounting evidence suggests zebrafish as a useful tool to study neurobiology of aggression, and its pharmacological and genetic regulation. Here, we discuss mechanisms of zebrafish aggression and their pharmacological, pharmacogenetic and pharmacogenomic models, as well as recent developments and existing challenges in this field. We also emphasize the growing utility of zebrafish models in translational neuropharmacological research of aggression, fostering future discoveries of potential therapeutic agents for aggressive behavior.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping