PUBLICATION
Acute toxicity and teratogenicity of α-mangostin in zebrafish embryos
- Authors
- Kittipaspallop, W., Taepavarapruk, P., Chanchao, C., Pimtong, W.
- ID
- ZDB-PUB-190104-1
- Date
- 2018
- Source
- Experimental biology and medicine (Maywood, N.J.) 243(15-16): 1212-1219 (Journal)
- Registered Authors
- Pimtong, Wittaya
- Keywords
- erythrotoxicity, pharmacology/toxicology, teratogenicity, xanthone, zebrafish, α-Mangostin
- MeSH Terms
- none
- PubMed
- 30602309 Full text @ Exp. Biol. Med. (Maywood)
Citation
Kittipaspallop, W., Taepavarapruk, P., Chanchao, C., Pimtong, W. (2018) Acute toxicity and teratogenicity of α-mangostin in zebrafish embryos. Experimental biology and medicine (Maywood, N.J.). 243(15-16):1212-1219.
Abstract
Impact statement α-Mangostin has been reported to have anticancer properties both in vitro and in vivo models. Although there are several studies that evaluated the toxicity of the compound in rodent models, we are the first to evaluate the teratogenicity of α-mangostin. In the present work, we found that α-mangostin induced mortality and malformations in zebrafish embryos. In addition, we exhibited that the compound also disrupted the reactive oxygen species and hemoglobin levels. These findings suggest that α-mangostin may possibly cause the same adverse effects on human health. The mechanisms of these toxicological effects of the compound will be further elucidated and the effects found in zebrafish embryos need to be verified in other animal models.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping