ZFIN ID: ZDB-PUB-181230-15
Zebrafish disease models in hematology: Highlights on biological and translational impact
Zizioli, D., Mione, M., Varinelli, M., Malagola, M., Bernardi, S., Alghisi, E., Borsani, G., Finazzi, D., Monti, E., Presta, M., Russo, D.
Date: 2018
Source: Biochimica et biophysica acta. Molecular basis of disease   1865(3): 620-633 (Review)
Registered Authors: Alghisi, Elisa, Borsani, Giuseppe, Mione, Marina, Presta, Marco
Keywords: Chemical screens, Hematopoiesis, Leukemia models, Xenotransplantation, Zebrafish
MeSH Terms:
  • Animals
  • Disease Models, Animal*
  • Drug Discovery/methods
  • Drug Screening Assays, Antitumor
  • Hematologic Neoplasms/pathology
  • Hematology/methods*
  • Hematology/trends*
  • Hematopoiesis
  • Humans
  • Translational Research, Biomedical*/methods
  • Translational Research, Biomedical*/trends
  • Zebrafish/physiology*
PubMed: 30593895 Full text @ BBA Molecular Basis of Disease
ABSTRACT
Zebrafish (Danio rerio) has proven to be a versatile and reliable in vivo experimental model to study human hematopoiesis and hematological malignancies. As vertebrates, zebrafish has significant anatomical and biological similarities to humans, including the hematopoietic system. The powerful genome editing and genome-wide forward genetic screening tools have generated models that recapitulate human malignant hematopoietic pathologies in zebrafish and unravel cellular mechanisms involved in these diseases. Moreover, the use of zebrafish models in large-scale chemical screens has allowed the identification of new molecular targets and the design of alternative therapies. In this review we summarize the recent achievements in hematological research that highlight the power of the zebrafish model for discovery of new therapeutic molecules. We believe that the model is ready to give an immediate translational impact into the clinic.
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