ZFIN ID: ZDB-PUB-181212-24
Chemical Screening Using a Zebrafish Model for Liver Progenitor Cell-Driven Liver Regeneration
Ko, S., Shin, D.
Date: 2019
Source: Methods in molecular biology (Clifton, N.J.)   1905: 83-90 (Other)
Registered Authors: Ko, Sungjin, Shin, Donghun
Keywords: Biliary epithelial cells, Chemical screen, Hepatocyte ablation, Liver progenitor cells, Nitroreductase
MeSH Terms:
  • Ablation Techniques
  • Animals
  • Cell Dedifferentiation
  • Cell Differentiation
  • Cell Proliferation
  • Disease Models, Animal
  • Hepatocytes/cytology*
  • Hepatocytes/metabolism
  • Liver Regeneration/drug effects*
  • Small Molecule Libraries/pharmacology*
  • Stem Cells/cytology*
  • Stem Cells/metabolism
  • Zebrafish
PubMed: 30536092 Full text @ Meth. Mol. Biol.
Following massive hepatocyte ablation in zebrafish, biliary epithelial cells can extensively give rise to hepatocytes through liver progenitor cells (LPCs). The zebrafish liver injury model is an important system to elucidate the molecular mechanisms underlying LPC-driven liver regeneration. Here, we describe a chemical screening method using the zebrafish model for identifying small molecules that can modulate LPC-driven liver regeneration.