PUBLICATION
Zebrafish models of diabetes-related CNS pathogenesis
- Authors
- Lakstygal, A.M., de Abreu, M.S., Lifanov, D., Wappler-Guzetta, E.A., Serikuly, N., Alpsychov, E.T., Wang, D., Wang, M., Tang, Z., Yan, N., Demin, K.A., Volgin, A.D., Amstislavskaya, T.G., Wang, J., Song, C., Alekseeva, P., Kalueff, A.V.
- ID
- ZDB-PUB-181127-86
- Date
- 2018
- Source
- Progress in neuro-psychopharmacology & biological psychiatry 92: 48-58 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Behavior, CNS, Diabetes, Glucose, Zebrafish
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology
- Brain/physiopathology
- Central Nervous System Diseases*/drug therapy
- Central Nervous System Diseases*/genetics
- Central Nervous System Diseases*/physiopathology
- Diabetes Mellitus*/drug therapy
- Diabetes Mellitus*/genetics
- Diabetes Mellitus*/physiopathology
- Disease Models, Animal*
- Humans
- Zebrafish*
- PubMed
- 30476525 Full text @ Prog. Neuropsychopharmacol. Biol. Psychiatry
Citation
Lakstygal, A.M., de Abreu, M.S., Lifanov, D., Wappler-Guzetta, E.A., Serikuly, N., Alpsychov, E.T., Wang, D., Wang, M., Tang, Z., Yan, N., Demin, K.A., Volgin, A.D., Amstislavskaya, T.G., Wang, J., Song, C., Alekseeva, P., Kalueff, A.V. (2018) Zebrafish models of diabetes-related CNS pathogenesis. Progress in neuro-psychopharmacology & biological psychiatry. 92:48-58.
Abstract
Diabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression and Alzheimer's disease. Despite active research in humans, rodent models and in-vitro systems, the pathogenetic link between DM and brain disorders remains poorly understood. Novel translational models and new model organisms are therefore essential to more fully study the impact of DM on CNS. The zebrafish (Danio rerio) is a powerful novel model species to study metabolic and CNS disorders. Here, we discuss how DM alters brain functions and behavior in zebrafish, and summarize their translational relevance to studying DM-related CNS pathogenesis in humans. We recognize the growing utility of zebrafish models in translational DM research, as they continue to improve our understanding of different brain pathologies associated with DM, and may foster the discovery of drugs that prevent or treat these diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping