PUBLICATION
Zinc mediates the action of androgen in acting as a downstream effector of LH on oocyte maturation in zebrafish
- Authors
- Li, J., Huang, D., Sun, X., Li, X., Cheng, C.H.K.
- ID
- ZDB-PUB-181114-18
- Date
- 2018
- Source
- Biology of reproduction 100(2): 468-478 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Androgens/metabolism*
- Animals
- Female
- Gene Expression Regulation/drug effects
- Luteinizing Hormone/genetics
- Luteinizing Hormone/metabolism*
- Oocytes/drug effects*
- Oocytes/physiology*
- Oogenesis/drug effects
- Receptors, Androgen
- Testosterone/pharmacology
- Zebrafish
- Zinc/pharmacology*
- PubMed
- 30418488 Full text @ Biol. Reprod.
Citation
Li, J., Huang, D., Sun, X., Li, X., Cheng, C.H.K. (2018) Zinc mediates the action of androgen in acting as a downstream effector of LH on oocyte maturation in zebrafish. Biology of reproduction. 100(2):468-478.
Abstract
The role of androgenic steroids on ovarian development has attracted much attention in recent years, but the molecular mechanism is still largely unknown. In this study, using zebrafish as a model, we found that the trace metal zinc mediates the action of androgen on oocyte maturation. The ovarian and serum testosterone is transiently stimulated by LH during oocyte maturation. Testosterone could mimic the action of LH on oocyte maturation, and its action appears to be independent of the classical nuclear androgen receptor. Consistent with a recent finding that a zinc transporter (Zip9) has been suggested as a novel androgen receptor, we found the labile zinc concentration could be induced by testosterone in the ovarian follicular cells, and zinc could mimic the action of testosterone on oocyte maturation and signaling. Moreover, the action of testosterone on oocyte maturation could be abolished by the chelation of zinc. Thus, the evidence support the notion that zinc could mediate the action of androgen on oocyte maturation in zebrafish. This finding would shed light on understanding the role of androgen in ovary development and the molecular mechanism of oocyte maturation in fish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping