PUBLICATION

Topography of a Visuomotor Transformation

Authors
Helmbrecht, T.O., Dal Maschio, M., Donovan, J.C., Koutsouli, S., Baier, H.
ID
ZDB-PUB-181106-17
Date
2018
Source
Neuron   100(6): 1429-1445.e4 (Journal)
Registered Authors
Baier, Herwig, Donovan, Joseph, Helmbrecht, Thomas
Keywords
hindbrain, motor map, optic tectum, optogenetics, reticular formation, space code, superior colliculus, tectal projectome, visuomotor transformation, zebrafish
MeSH Terms
  • Animals
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • Luminescent Proteins/genetics
  • Luminescent Proteins/metabolism
  • Zebrafish
  • Larva
  • Visual Pathways/cytology*
  • Visual Pathways/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Neurons/physiology*
  • Transcription Factors/genetics
  • Transcription Factors/metabolism
  • Calcium/metabolism
  • Optogenetics
  • Cues
  • Brain Mapping*
  • Photic Stimulation
  • Superior Colliculi/cytology
  • Animals, Genetically Modified
  • Motor Activity/physiology*
  • Visual Perception/physiology*
  • Channelrhodopsins/genetics
  • Channelrhodopsins/metabolism
(all 25)
PubMed
30392799 Full text @ Neuron
Abstract
The brain converts perceptual information into appropriate patterns of muscle activity depending on the categorization and localization of sensory cues. Sensorimotor information might either be encoded by distributed networks or by "labeled lines" connecting sensory channels to dedicated behavioral pathways. Here we investigate, in the context of natural behavior, how the tectum of larval zebrafish can inform downstream premotor areas. Optogenetic mapping revealed a tectal motor map underlying locomotor maneuvers for escape and approach. Single-cell reconstructions and high-resolution functional imaging showed that two spatially segregated and uncrossed descending axon tracts selectively transmit approach and escape signals to the hindbrain. Moreover, the approach pathway conveys information about retinotopic target coordinates to specific premotor ensembles via spatially ordered axonal projections. This topographic organization supports a tectum-generated space code sufficient to steer orienting movements. We conclude that specific labeled lines guide object-directed behavior in the larval zebrafish brain.
Genes / Markers
Figures
Figure Gallery (6 images)
Show all Figures
Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
jf5TgTransgenic Insertion
    mpn101TgTransgenic Insertion
      mpn143TgTransgenic Insertion
        mpn404TgTransgenic Insertion
          s318tTgTransgenic Insertion
            s1013tEtTransgenic Insertion
              s1985tTgTransgenic Insertion
                w2
                  		Point Mutation
                  1 - 8 of 8
                  Show
                  Human Disease / Model
                  No data available
                  Sequence Targeting Reagents
                  No data available
                  Fish
                  No data available
                  Antibodies
                  No data available
                  Orthology
                  No data available
                  Engineered Foreign Genes
                  Marker Marker Type Name
                  GAL4EFGGAL4
                  GCaMPEFGGCaMP
                  GFPEFGGFP
                  mCherryEFGmCherry
                  TagRFPEFGTagRFP
                  1 - 5 of 5
                  Show
                  Mapping
                  No data available
                  Your Input Welcome
                  We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
                  Citation
                  Helmbrecht, T.O., Dal Maschio, M., Donovan, J.C., Koutsouli, S., Baier, H. (2018) Topography of a Visuomotor Transformation. Neuron. 100(6):1429-1445.e4.