PUBLICATION
Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin
- Authors
- Fontenas, L., Kucenas, S.
- ID
- ZDB-PUB-181026-18
- Date
- 2018
- Source
- Frontiers in Cellular Neuroscience 12: 333 (Review)
- Registered Authors
- Fontenas, Laura, Kucenas, Sarah
- Keywords
- boundary cap cell, motor exit point glia, myelin, oligodendrocyte, schwann cell, zebrafish
- MeSH Terms
- none
- PubMed
- 30356886 Full text @ Front. Cell. Neurosci.
Citation
Fontenas, L., Kucenas, S. (2018) Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin. Frontiers in Cellular Neuroscience. 12:333.
Abstract
Oligodendrocytes (OLs) and Schwann cells (SCs) have traditionally been thought of as the exclusive myelinating glial cells of the central and peripheral nervous systems (CNS and PNS), respectively, for a little over a century. However, recent studies demonstrate the existence of a novel, centrally-derived peripheral glial population called motor exit point (MEP) glia, which myelinate spinal motor root axons in the periphery. Until recently, the boundaries that exist between the CNS and PNS, and the cells permitted to cross them, were mostly described based on fixed histological collections and static lineage tracing. Recent work in zebrafish using in vivo, time-lapse imaging has shed light on glial cell interactions at the MEP transition zone and reveals a more complex picture of myelination both centrally and peripherally.
Genes / Markers
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Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
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