PUBLICATION
Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions
- Authors
- Volgin, A.D., Yakovlev, O.A., Demin, K.A., de Abreu, M.S., Alekseeva, P.A., Friend, A.J., Lakstygal, A.M., Amstislavskaya, T.G., Bao, W., Song, C., Kalueff, A.V.
- ID
- ZDB-PUB-181016-15
- Date
- 2018
- Source
- Journal of neuroscience research 97(4): 402-413 (Review)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- gene-environment interactions, individual differences, personalized psychiatry, zebrafish
- MeSH Terms
-
- Animals
- Behavioral Medicine
- Central Nervous System
- Disease Models, Animal*
- Female
- Gene-Environment Interaction
- Individuality
- Male
- Mental Disorders*
- Precision Medicine/trends*
- Sex
- Translational Research, Biomedical
- Zebrafish*
- PubMed
- 30320468 Full text @ J. Neurosci. Res.
Citation
Volgin, A.D., Yakovlev, O.A., Demin, K.A., de Abreu, M.S., Alekseeva, P.A., Friend, A.J., Lakstygal, A.M., Amstislavskaya, T.G., Bao, W., Song, C., Kalueff, A.V. (2018) Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions. Journal of neuroscience research. 97(4):402-413.
Abstract
Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient-centered personalized psychiatry.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping