PUBLICATION
Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish
- Authors
- Bhandiwad, A.A., Raible, D.W., Rubel, E.W., Sisneros, J.A.
- ID
- ZDB-PUB-180908-7
- Date
- 2018
- Source
- Journal of the Association for Research in Otolaryngology : JARO 19(6): 741-752 (Journal)
- Registered Authors
- Raible, David
- Keywords
- behavior, damage, hearing, inner ear, prepulse inhibition
- MeSH Terms
-
- Animals
- Behavior, Animal
- Electric Stimulation
- Larva/physiology
- Noise
- Quinoxalines
- Receptors, AMPA/metabolism*
- Reflex, Startle*
- Valine/analogs & derivatives
- Zebrafish/physiology*
- alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
- PubMed
- 30191425 Full text @ J. Assoc. Res. Otolaryngol.
Citation
Bhandiwad, A.A., Raible, D.W., Rubel, E.W., Sisneros, J.A. (2018) Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish. Journal of the Association for Research in Otolaryngology : JARO. 19(6):741-752.
Abstract
Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception. We studied the effects of noise exposure on sensorimotor behaviors of larval (5-7 days post-fertilization) zebrafish (Danio rerio), particularly the auditory-evoked startle response and hearing sensitivity to acoustic startle stimuli. We observed a temporary 10-15 dB decrease in startle response threshold after 18 h of flat-spectrum noise exposure at 20 dB re·1 ms-2. Larval zebrafish also exhibited decreased habituation to startle-inducing stimuli following noise exposure. The noise-induced sensitization was not due to changes in absolute hearing thresholds, but was specific to the auditory-evoked escape responses. The observed noise-induced sensitization was disrupted by AMPA receptor blockade using DNQX, but not NMDA receptor blockade. Together, these experiments suggest a complex effect of noise exposure on the neural circuits mediating auditory-evoked behaviors in larval zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping