PUBLICATION
Models for Studying Myelination, Demyelination and Remyelination
- Authors
- Osorio-Querejeta, I., Sáenz-Cuesta, M., Muñoz-Culla, M., Otaegui, D.
- ID
- ZDB-PUB-180807-12
- Date
- 2017
- Source
- NeuroMolecular Medicine 19: 181-192 (Review)
- Registered Authors
- Keywords
- Cell culture, Demyelination, Experimental models, Multiple sclerosis, Neurodegeneration, Remyelination
- MeSH Terms
-
- Virus Diseases/physiopathology
- Animals, Genetically Modified
- Oligodendrocyte Precursor Cells/cytology
- Oligodendrocyte Precursor Cells/drug effects
- Oligodendrocyte Precursor Cells/metabolism
- Animals
- Species Specificity
- Axons/metabolism
- Toxicity Tests
- Zebrafish/physiology
- Demyelinating Diseases/chemically induced
- Demyelinating Diseases/physiopathology*
- Demyelinating Diseases/virology
- Schwann Cells/metabolism
- Encephalomyelitis, Autoimmune, Experimental/physiopathology
- Myelin Sheath/drug effects
- Myelin Sheath/physiology*
- Coculture Techniques
- Humans
- Models, Animal*
- Oligodendroglia/drug effects
- Oligodendroglia/metabolism
- Cells, Cultured
- Mice
- PubMed
- 28536996 Full text @ Neuromolecular Med.
Citation
Osorio-Querejeta, I., Sáenz-Cuesta, M., Muñoz-Culla, M., Otaegui, D. (2017) Models for Studying Myelination, Demyelination and Remyelination. NeuroMolecular Medicine. 19:181-192.
Abstract
One of the most widely studied demyelinating diseases is multiple sclerosis, which is characterised by the appearance of demyelinating plaques, followed by myelin regeneration. Nevertheless, with disease progression, remyelination tends to fail, increasing the characteristic neurodegeneration of the disease. It is essential to understand the mechanisms that operate in the processes of myelination, demyelination and remyelination to develop treatments that promote the production of new myelin, thereby protecting the central nervous system. A huge variety of models have been developed to help improve our understanding of these processes. Nevertheless, no single model allows us to study all the processes involved in remyelination and usually more than one is needed to provide a full picture of related mechanisms. In this review, we summarise the most commonly used models for studying myelination, demyelination and remyelination and we analyse them critically to outline the most suitable ways of using them.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping