PUBLICATION
Developing and interpreting aqueous functional assays for comparative property-activity relationships of different nanoparticles
- Authors
- Kidd, J.M., Hanigan, D., Truong, L., Hristovski, K., Tanguay, R., Westerhoff, P.
- ID
- ZDB-PUB-180727-4
- Date
- 2018
- Source
- The Science of the total environment 628-629: 1609-1616 (Journal)
- Registered Authors
- Tanguay, Robyn L.
- Keywords
- Exposure, Fate, Hazard, Nanoparticle, Water
- MeSH Terms
- none
- PubMed
- 30045577 Full text @ Sci. Total Environ.
Citation
Kidd, J.M., Hanigan, D., Truong, L., Hristovski, K., Tanguay, R., Westerhoff, P. (2018) Developing and interpreting aqueous functional assays for comparative property-activity relationships of different nanoparticles. The Science of the total environment. 628-629:1609-1616.
Abstract
It is difficult to relate intrinsic nanomaterial properties to their functional behavior in the environment. Unlike frameworks for dissolved organic chemicals, there are few frameworks comparing multiple and inter-related properties of engineered nanomaterials (ENMs) to their fate, exposure, and hazard in environmental systems. We developed and evaluated reproducibility and inter-correlation of 12 physical, chemical, and biological functional assays in water for eight different engineered nanomaterials (ENMs) and interpreted results using activity-profiling radar plots. The functional assays were highly reproducible when run in triplicate (average coefficient of variation [CV]=6.6%). Radar plots showed that each nanomaterial exhibited unique activity profiles. Reactivity assays showed dissolution or aggregation potential for some ENMs. Surprisingly, multi-walled carbon nanotubes (MWCNTs) exhibited movement in a magnetic field. We found high inter-correlations between cloud point extraction (CPE) and distribution to sewage sludge (R2=0.99), dissolution at pH8 and pH4.9 (R2=0.98), and dissolution at pH8 and zebrafish mortality at 24hpf (R2=0.94). Additionally, most ENMs tend to distribute out of water and into other phases (i.e., soil surfaces, surfactant micelles, and sewage sludge). The activity-profiling radar plots provide a framework and estimations of likely ENM disposition in the environment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping