Community Action Needed: Please respond to the NIH RFI
ZFIN ID: ZDB-PUB-180725-12
Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models
Johansen, M.D., Kasparian, J.A., Hortle, E., Britton, W.J., Purdie, A.C., Oehlers, S.H.
Date: 2018
Source: Developmental and comparative immunology   88: 169-172 (Journal)
Registered Authors: Hortle, Elinor, Oehlers, Stefan
Keywords: Foam cell, Granuloma, Lipid, Mycobacterium, Pathogenesis, Zebrafish
MeSH Terms:
  • Animals
  • Antigens, Bacterial/immunology
  • Bacterial Proteins/immunology
  • Cell Transdifferentiation/immunology
  • Disease Models, Animal
  • Foam Cells/physiology*
  • Granuloma/immunology
  • Granuloma/microbiology
  • Humans
  • Lipid Metabolism/immunology
  • Macrophages/physiology
  • Mycobacterium Infections, Nontuberculous/immunology*
  • Mycobacterium Infections, Nontuberculous/microbiology
  • Mycobacterium marinum/immunology*
  • Mycobacterium marinum/pathogenicity
  • Mycobacterium tuberculosis/immunology
  • Mycobacterium tuberculosis/pathogenicity
  • Tuberculosis/immunology*
  • Tuberculosis/microbiology
  • Zebrafish/physiology*
PubMed: 30040967 Full text @ Dev. Comp. Immunol.
Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.