Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models
- Johansen, M.D., Kasparian, J.A., Hortle, E., Britton, W.J., Purdie, A.C., Oehlers, S.H.
- Developmental and comparative immunology 88: 169-172 (Journal)
- Registered Authors
- Hortle, Elinor, Oehlers, Stefan
- Foam cell, Granuloma, Lipid, Mycobacterium, Pathogenesis, Zebrafish
- MeSH Terms
- Antigens, Bacterial/immunology
- Bacterial Proteins/immunology
- Cell Transdifferentiation/immunology
- Disease Models, Animal
- Foam Cells/physiology*
- Lipid Metabolism/immunology
- Mycobacterium Infections, Nontuberculous/immunology*
- Mycobacterium Infections, Nontuberculous/microbiology
- Mycobacterium marinum/immunology*
- Mycobacterium marinum/pathogenicity
- Mycobacterium tuberculosis/immunology
- Mycobacterium tuberculosis/pathogenicity
- 30040967 Full text @ Dev. Comp. Immunol.
Johansen, M.D., Kasparian, J.A., Hortle, E., Britton, W.J., Purdie, A.C., Oehlers, S.H. (2018) Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models. Developmental and comparative immunology. 88:169-172.
Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes