PUBLICATION
Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit[ n]uril ( n = 7, 8)
- Authors
- Yin, H., Huang, Q., Zhao, W., Bardelang, D., Siri, D., Chen, X., Lee, S.M.Y., Wang, R.
- ID
- ZDB-PUB-180703-10
- Date
- 2018
- Source
- The Journal of organic chemistry 83: 4882-4887 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Bridged-Ring Compounds/chemistry*
- Bridged-Ring Compounds/pharmacology*
- Capsules
- Cardiotonic Agents/chemistry*
- Cardiotonic Agents/pharmacology*
- Dose-Response Relationship, Drug
- Halogens/chemistry*
- Heart/drug effects
- Imidazoles/chemistry*
- Imidazoles/pharmacology*
- Mice
- RAW 264.7 Cells
- Structure-Activity Relationship
- Zebrafish
- PubMed
- 29616817 Full text @ J. Org. Chem.
Citation
Yin, H., Huang, Q., Zhao, W., Bardelang, D., Siri, D., Chen, X., Lee, S.M.Y., Wang, R. (2018) Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit[ n]uril ( n = 7, 8). The Journal of organic chemistry. 83:4882-4887.
Abstract
This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[ n]uril family and provides new insights for halonium-cucurbit[ n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping