PUBLICATION
Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio
- Authors
- Hou, J., Liu, H., Wang, L., Duan, L., Li, S., Wang, X.
- ID
- ZDB-PUB-180627-11
- Date
- 2018
- Source
- Environmental science & technology 52(14): 7996-8004 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Comet Assay
- Humans
- Metal Nanoparticles*
- Nanoparticles*
- Oxides
- Zebrafish
- Zinc Oxide*
- PubMed
- 29944347 Full text @ Env. Sci. Tech.
Citation
Hou, J., Liu, H., Wang, L., Duan, L., Li, S., Wang, X. (2018) Molecular Toxicity of Metal Oxide Nanoparticles in Danio rerio. Environmental science & technology. 52(14):7996-8004.
Abstract
Metal oxide nanoparticles can exert adverse effects on humans and aquatic organisms, however, their toxic mechanisms are still unclear. We investigated the toxic effects and mechanisms of copper oxide, zinc oxide, and nickel oxide nanoparticles in Danio rerio using microarray analysis and the comet assay. Copper oxide nanoparticles were more lethal than the other metal oxide nanoparticles. Gene ontology analysis of genes that were differentially expressed following exposure to all three metal oxide nanoparticles showed that the nanoparticles mainly affected nucleic acid metabolism in the nucleus via alterations in nucleic acid binding. KEGG analysis classified the differentially expressed genes to the genotoxicity-related pathways "cell cycle", "Fanconi anemia", "DNA replication", and "homologous recombination". The toxicity of metal oxide nanoparticles may be related to impairments in DNA synthesis and repair, as well as to increased production of reactive oxygen species.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping