PUBLICATION
Identification of the actc1c cardiac actin gene in zebrafish
- Authors
- Ojehomon, M., Alderman, S.L., Sandhu, L., Sutcliffe, S., Van Raay, T., Gillis, T.E., Dawson, J.F.
- ID
- ZDB-PUB-180622-12
- Date
- 2018
- Source
- Progress in Biophysics and Molecular Biology 138: 32-37 (Journal)
- Registered Authors
- Keywords
- actin orthologs, actin protein, in situ hybridization, sequence conservation, zebrafish
- MeSH Terms
-
- Actins/chemistry
- Actins/genetics*
- Actins/metabolism
- Amino Acid Sequence
- Animals
- Humans
- Myocardium/metabolism*
- Zebrafish/genetics*
- PubMed
- 29913180 Full text @ Prog. Biophys. Mol. Biol.
Citation
Ojehomon, M., Alderman, S.L., Sandhu, L., Sutcliffe, S., Van Raay, T., Gillis, T.E., Dawson, J.F. (2018) Identification of the actc1c cardiac actin gene in zebrafish. Progress in Biophysics and Molecular Biology. 138:32-37.
Abstract
Zebrafish is rapidly becoming a key model organism for studying a variety of biological processes from molecules to organisms. Interactions involving actin, a contractile protein and part of the cytoskeleton, are regulated by actin binding proteins in the majority of physiological processes in eukaryotic cells. To understand the contribution of actin proteins to the physiological processes of zebrafish, it is important to identify the diverse isoforms of actin encoded by its genome; however, significant sequence identity complicates isoform assignments. Through a combination of human-directed sequence and functional analysis, we have assigned and performed localization of actc1c, a previously undesignated cardiac actin gene, and propose an updated assignment of α-actin protein isoform identities in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping