PUBLICATION
Impacts of isopyrazam exposure on the development of early-life zebrafish (Danio rerio)
- Authors
- Yao, H., Xu, X., Zhou, Y., Xu, C.
- ID
- ZDB-PUB-180609-7
- Date
- 2018
- Source
- Environmental science and pollution research international 25(24): 23799-23808 (Journal)
- Registered Authors
- Keywords
- Developmental toxicity, Isopyrazam, Oxidative stress, Succinate dehydrogenase inhibitor, Zebrafish embryo
- MeSH Terms
-
- Norbornanes/toxicity*
- Succinate Dehydrogenase/physiology
- Zebrafish Proteins/physiology
- Fungicides, Industrial/toxicity*
- Oxidative Stress/drug effects
- Embryo, Nonmammalian/abnormalities
- Embryo, Nonmammalian/drug effects*
- Embryo, Nonmammalian/physiology
- Pyrazoles/toxicity*
- Zebrafish/embryology*
- Zebrafish/physiology
- Water Pollutants, Chemical/toxicity*
- Embryonic Development/drug effects
- Female
- Heart Rate/drug effects
- Male
- Animals
- Head/abnormalities
- PubMed
- 29876854 Full text @ Environ. Sci. Pollut. Res. Int.
Citation
Yao, H., Xu, X., Zhou, Y., Xu, C. (2018) Impacts of isopyrazam exposure on the development of early-life zebrafish (Danio rerio). Environmental science and pollution research international. 25(24):23799-23808.
Abstract
Isopyrazam (IPZ) is a broad spectrum succinate dehydrogenase inhibitor fungicide. Little is known about its potential ecological risks of aquatic organisms recently. The present study examined the embryonic development effects of zebrafish exposed to IPZ under static condition using a fish embryo toxicity test. The lowest observed effect concentration of IPZ was 0.025 mg/L in 4-day exposure. Developmental abnormalities, including edema, small head deformity, body deformation and decreased pigmentation, and mortality were observed in zebrafish embryos of 0.05 mg/L and higher concentrations, which shown concentration dependency. The heart rate of zebrafish was disrupted by IPZ. Moreover, enzyme and gene experiments shown that IPZ exposure caused oxidative stress of zebrafish. Furthermore, it induced a decrease of succinate dehydrogenase (SDH) enzyme activity and gene transcription level in zebrafish larvae. It can be speculated that IPZ may have a lethal effect on zebrafish, which is accompanied by decreased SDH activity, oxidative stress, and abnormality. These results provide toxicological data about the IPZ on aquatic non-target organisms, which could be useful for further understanding potential environmental risks.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping