PUBLICATION
Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane
- Authors
- Jin, M.Q., Zhang, D., Zhang, Y., Zhou, S.S., Lu, X.T., Zhao, H.T.
- ID
- ZDB-PUB-180509-15
- Date
- 2018
- Source
- Journal of Zhejiang University. Science. B 19: 400-408 (Journal)
- Registered Authors
- Keywords
- Decabromodiphenylethane; Flame retardant; Danio rerio; Neurotoxicity
- MeSH Terms
-
- Abnormalities, Drug-Induced/etiology
- Animals
- Apoptosis/drug effects
- Behavior, Animal/drug effects
- Bromobenzenes/toxicity*
- Geologic Sediments/analysis*
- Larva/drug effects
- Neurotoxicity Syndromes/etiology*
- Water Pollutants, Chemical/toxicity*
- Zebrafish/embryology*
- PubMed
- 29732751 Full text @ J. Zhejiang Univ. Sci. B
- CTD
- 29732751
Citation
Jin, M.Q., Zhang, D., Zhang, Y., Zhou, S.S., Lu, X.T., Zhao, H.T. (2018) Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane. Journal of Zhejiang University. Science. B. 19:400-408.
Abstract
Decabromodiphenylethane (DBDPE) has been widely used as an alternative flame retardant due to the restriction or phase-out of traditional polybrominated diphenyl ethers (PBDEs), and is of increasing concern regarding its ubiquity, persistence, and potential adverse effects. In the present study, the toxicological effects of DBDPE were evaluated using zebrafish as an in vivo model. Upon being exposed to DBDPE-polluted sediments for a short term, it was found that the mortality and malformation of zebrafish (including edema, bent notochord, and bent tail) were not affected even at the highest concentration tested (1000.0 µg/kg dry sediment). Regarding behavioral responses, it was found that zebrafish larvae of 48 hours post fertilization (hpf) in all groups escaped successfully with a touch to the dorsal fin. However, when exposed to the highest DBDPE concentration, the larvae of 120 hpf exhibited significantly smaller distances as compared to the control. Moreover, the results of the acetylcholinesterase (AChE) activity, the expression levels of two important nerve-related genes, and the cell apoptosis all indicated that DBDPE posed low neurotoxicity in embryo-larval zebrafish. The results in this study shed some light on the potential risks of DBDPE in the real environment and highlight the application of the sediment exposure route in the future.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping