|ZFIN ID: ZDB-PUB-180508-5|
Zebrafish heart failure models: opportunities and challenges
Shi, X., Chen, R., Zhang, Y., Yun, J., Brand-Arzamendi, K., Liu, X., Wen, X.Y.
|Source:||Amino Acids 50(7): 787-798 (Review)|
|Registered Authors:||Wen, Xiao-Yan|
|Keywords:||Cardiomyopathy, Chemical compound, Heart failure, Mitochondria, Sarcomere, Zebrafish|
|PubMed:||29725858 Full text @ Amino Acids|
Shi, X., Chen, R., Zhang, Y., Yun, J., Brand-Arzamendi, K., Liu, X., Wen, X.Y. (2018) Zebrafish heart failure models: opportunities and challenges. Amino Acids. 50(7):787-798.
ABSTRACTHeart failure is a complex pathophysiological syndrome of pumping functional failure that results from injury, infection or toxin-induced damage on the myocardium, as well as genetic influence. Gene mutations associated with cardiomyopathies can lead to various pathologies of heart failure. In recent years, zebrafish, Danio rerio, has emerged as an excellent model to study human cardiovascular diseases such as congenital heart defects, cardiomyopathy, and preclinical development of drugs targeting these diseases. In this review, we will first summarize zebrafish genetic models of heart failure arose from cardiomyopathy, which is caused by mutations in sarcomere, calcium or mitochondrial-associated genes. Moreover, we outline zebrafish heart failure models triggered by chemical compounds. Elucidation of these models will improve the understanding of the mechanism of pathogenesis and provide potential targets for novel therapies.
ADDITIONAL INFORMATION No data available