PUBLICATION
Learning from regeneration research organisms: The circuitous road to scar free wound healing
- Authors
- Erickson, J.R., Echeverri, K.
- ID
- ZDB-PUB-180418-68
- Date
- 2018
- Source
- Developmental Biology 433: 144-154 (Review)
- Registered Authors
- Echeverri, Karen
- Keywords
- Collagen, Regeneration, Scar, Skin
- MeSH Terms
-
- Amphibians/physiology
- Animals
- Cicatrix/physiopathology
- Cicatrix/prevention & control*
- Extracellular Matrix/metabolism
- Fibroblasts/physiology
- Gene Expression Regulation
- Humans
- Invertebrates/physiology
- Keratinocytes/physiology
- Mammals/physiology
- Models, Animal*
- Prenatal Injuries/physiopathology
- Regeneration/physiology
- Skin/cytology
- Skin/embryology
- Species Specificity
- Wound Healing/immunology
- Wound Healing/physiology*
- Zebrafish/physiology
- PubMed
- 29179946 Full text @ Dev. Biol.
Citation
Erickson, J.R., Echeverri, K. (2018) Learning from regeneration research organisms: The circuitous road to scar free wound healing. Developmental Biology. 433:144-154.
Abstract
The skin is the largest organ in the body and plays multiple essential roles ranging from regulating temperature, preventing infection and ultimately defining who we are physically. It is a highly dynamic organ that constantly replaces the outermost cells throughout life. However, when faced with a major injury, human skin cannot restore a significant lesion to its original functionality, instead a reparative scar is formed. In contrast to this, many other species have the unique ability to regenerate full thickness skin without formation of scar tissue. Here we review recent advances in the field that shed light on how the skin cells in regenerative species react to injury to prevent scar formation versus scar forming humans.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping