PUBLICATION
Nodal and BMP dispersal during early zebrafish development
- Authors
- Rogers, K.W., Müller, P.
- ID
- ZDB-PUB-180418-36
- Date
- 2018
- Source
- Developmental Biology 447(1): 14-23 (Review)
- Registered Authors
- Müller, Patrick, Rogers, Katherine
- Keywords
- none
- MeSH Terms
-
- Animals
- Bone Morphogenetic Proteins/genetics
- Bone Morphogenetic Proteins/metabolism*
- Embryonic Development/physiology*
- Endoderm/cytology
- Endoderm/embryology
- Mesoderm/cytology
- Mesoderm/embryology
- Models, Biological*
- Nodal Signaling Ligands/genetics
- Nodal Signaling Ligands/metabolism*
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 29653088 Full text @ Dev. Biol.
Citation
Rogers, K.W., Müller, P. (2018) Nodal and BMP dispersal during early zebrafish development. Developmental Biology. 447(1):14-23.
Abstract
The secreted TGF-β superfamily signals Nodal and BMP coordinate the patterning of vertebrate embryos. Nodal specifies endoderm and mesoderm during germ layer formation, and BMP specifies ventral fates and patterns the dorsal/ventral axis. Five major models have been proposed to explain how the correct distributions of Nodal and BMP are achieved within tissues to orchestrate embryogenesis: source/sink, transcriptional determination, relay, self-regulation, and shuttling. Here, we discuss recent experiments probing these signal dispersal models, focusing on early zebrafish development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping