PUBLICATION
Effects of Fluoxetine and Potential Antidepressant 8-Trifluoromethyl 1,2,3,4,5-Benzopentathiepin-6-Amine Hydrochloride (TC-2153) on Behavior of Danio rerio Fish in the Novel Tank Test and Brain Content of Biogenic Amines and Their Metabolites
- Authors
- Sinyakova, N.A., Kulikova, E.A., Englevskii, N.A., Kulikov, A.V.
- ID
- ZDB-PUB-180327-10
- Date
- 2018
- Source
- Bulletin of experimental biology and medicine 164(5): 620-623 (Journal)
- Registered Authors
- Keywords
- Danio rerio, TC-2153, fluoxetine, monoamines, “novel tank” test
- MeSH Terms
-
- Animals
- Antidepressive Agents/pharmacology*
- Behavior, Animal/drug effects
- Benzothiepins/pharmacology*
- Biogenic Amines/metabolism*
- Brain/drug effects*
- Brain/metabolism*
- Dopamine/metabolism
- Fluoxetine/pharmacology*
- Norepinephrine/metabolism
- Serotonin/metabolism
- Zebrafish
- PubMed
- 29577201 Full text @ Bull. Exp. Biol. Med.
Citation
Sinyakova, N.A., Kulikova, E.A., Englevskii, N.A., Kulikov, A.V. (2018) Effects of Fluoxetine and Potential Antidepressant 8-Trifluoromethyl 1,2,3,4,5-Benzopentathiepin-6-Amine Hydrochloride (TC-2153) on Behavior of Danio rerio Fish in the Novel Tank Test and Brain Content of Biogenic Amines and Their Metabolites. Bulletin of experimental biology and medicine. 164(5):620-623.
Abstract
We compared the effect of a new potential antidepressant 8-trifluoromethyl 1,2,3,4,5-benzopentathiepine-6-amine hydrochloride (TC-2153) and classical antidepressant fluoxetine in a dose of 0.25 mg/liter on the behavior of Danio rerio in the "novel tank" test and content of biogenic amines and their metabolites in the brain. Fluoxetine alone and TC-2153 alone significantly increased the time spent in the upper part of the tank and insignificantly reduced motor activity. Combined exposure of fishes in the solution containing potential and classical antidepressants potentiated their effects on both parameters. The compounds did not affect brain contents of serotonin, dopamine, and norepinephrine. At the same time, fluoxetine, but not TC-2153, reduced brain content of the main serotonin metabolite 5-hydroxyindole acetic acid.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping